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This book focuses on the structural, biochemical, and diverse
functional properties of the endothelial luminal membrane
glycocalyx (ELMG), an organelle which constitutes the endothelial
cell "membrane." It is intended to provide the newcomer with a
broad, basic, and brief perspective of the luminal endothelial
vascular membrane, and for the more established investigator, a
basic overview and integrated perspective of the "universe" we
explore. The endothelium is an assortment of heterogeneous
regulatory cells whose cytoplasm and cell membranes are joined,
forming functional units. There is a tremendous amount of
literature on the endothelial cell, constituting seemingly isolated
and distinct fields of encapsulated research. However, the
multifunctional properties of some molecules give rise to an
overlap of findings, frequently ignored between the different
fields. The book is divided into three parts. The first part
concentrates on the structure of the ELMG, with emphasis on
morphological and biochemical composition. The importance of the
chemical composition to the physiological functions of the ELMG,
such as sieving properties, pharmacology, and flow sensing, is the
focus of the second part of the book. Finally, some of the
pathologies associated with ELMG dysfunction are explored in the
last section. The aim is to provide basic and well-established
knowledge in the various individual fields, identify the current
concepts in each area, and discuss their respective strengths and
weaknesses (including hidden problems). Finally, the overall goal
is to integrate areas where overlap is clearly indicated, bringing
them all together to provide the first ever basic, integrative,
panoramic bird's-eye view of the field.
The principal objective of this symposium was to bring together
investigators from all over the world who work in diverse areas of
research but share a common interest in the physiologic and
pathophysiologic funetions of the nueleoside adenosine. In 1978,
the "International Conference on Physiological and Regulatory
Funetions of Adenosine and Adenine Nueleotides," held in Banff,
Canada, served as an effective catalyst in enabling scientists with
differ ent points of view to exchange information and ideas on this
subject. Since 1978, the amount of research on different as peets
of adenosine metabolism, mechanism of action, transport, and
function in various tissues (in both nor maI and abnormal states)
has increased exponentially, and there was an urgent need for
another meeting for updating information on this burgeoning
subject. The focus of the meeting was extremely sharp, but the
scope of the subject material was very broad. Scientists
categorized as chemists, biochemists, physiologists,
pharmacologists, and immunologists, working with cells and eelI
fragments, with tissues such as heart, brain, musele, fat, kidney,
and with human beings having immune deficiency diseases
participated in the sym posium. They had an opportunity to air
their differences, reinforce their areas of agreement, and, most
important, they educated each other with respeet to research on
adenosine; it is hoped that they also enriched their own research
programs from the information they gained from their fellow
participants."
This proceedings volume gathers selected, revised papers presented
at the X International Meeting on Lorentzian Geometry (GeLoCor
2021), virtually held at the University of Cordoba, Spain, on
February 1-5, 2021. It includes surveys describing the
state-of-the-art in specific areas, and a selection of the most
relevant results presented at the conference. Taken together, the
papers offer an invaluable introduction to key topics discussed at
the conference and an overview of the main techniques in use today.
This volume also gathers extended revisions of key studies in this
field. Bringing new results and examples, these unique
contributions offer new perspectives to the original problems and,
in most cases, extend and reinforce the robustness of previous
findings. Hosted every two years since 2001, the International
Meeting on Lorentzian Geometry has become one of the main events
bringing together the leading experts on Lorentzian geometry. In
this volume, the reader will find studies on spatial and null
hypersurfaces, low regularity in general relativity, conformal
structures, Lorentz-Finsler spacetimes, and more. Given its scope,
the book will be of interest to both young and experienced
mathematicians and physicists whose research involves general
relativity and semi-Riemannian geometry.
The principal objective of this symposium was to bring together
investigators from all over the world who work in diverse areas of
research but share a common interest in the physiologic and
pathophysiologic funetions of the nueleoside adenosine. In 1978,
the "International Conference on Physiological and Regulatory
Funetions of Adenosine and Adenine Nueleotides," held in Banff,
Canada, served as an effective catalyst in enabling scientists with
differ ent points of view to exchange information and ideas on this
subject. Since 1978, the amount of research on different as peets
of adenosine metabolism, mechanism of action, transport, and
function in various tissues (in both nor maI and abnormal states)
has increased exponentially, and there was an urgent need for
another meeting for updating information on this burgeoning
subject. The focus of the meeting was extremely sharp, but the
scope of the subject material was very broad. Scientists
categorized as chemists, biochemists, physiologists,
pharmacologists, and immunologists, working with cells and eelI
fragments, with tissues such as heart, brain, musele, fat, kidney,
and with human beings having immune deficiency diseases
participated in the sym posium. They had an opportunity to air
their differences, reinforce their areas of agreement, and, most
important, they educated each other with respeet to research on
adenosine; it is hoped that they also enriched their own research
programs from the information they gained from their fellow
participants."
This book focuses on the structural, biochemical, and diverse
functional properties of the endothelial luminal membrane
glycocalyx (ELMG), an organelle which constitutes the endothelial
cell "membrane." It is intended to provide the newcomer with a
broad, basic, and brief perspective of the luminal endothelial
vascular membrane, and for the more established investigator, a
basic overview and integrated perspective of the "universe" we
explore. The endothelium is an assortment of heterogeneous
regulatory cells whose cytoplasm and cell membranes are joined,
forming functional units. There is a tremendous amount of
literature on the endothelial cell, constituting seemingly isolated
and distinct fields of encapsulated research. However, the
multifunctional properties of some molecules give rise to an
overlap of findings, frequently ignored between the different
fields. The book is divided into three parts. The first part
concentrates on the structure of the ELMG, with emphasis on
morphological and biochemical composition. The importance of the
chemical composition to the physiological functions of the ELMG,
such as sieving properties, pharmacology, and flow sensing, is the
focus of the second part of the book. Finally, some of the
pathologies associated with ELMG dysfunction are explored in the
last section. The aim is to provide basic and well-established
knowledge in the various individual fields, identify the current
concepts in each area, and discuss their respective strengths and
weaknesses (including hidden problems). Finally, the overall goal
is to integrate areas where overlap is clearly indicated, bringing
them all together to provide the first ever basic, integrative,
panoramic bird's-eye view of the field.
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