In this issue of Medical Clinics of North America, guest editors Drs. Geno Merli and Raghu Kolluri bring their considerable expertise to the topic of Vascular Medicine. Top experts in the field provide evidence-based recommendations on vascular issues and diseases for those in primary care, non-vascular medicine specialists, and nurse practitioners, including articles on atherosclerotic disease, peripheral artery disease, lower extremity vascular ulcers, vasculitis, vascular imaging for the primary care provider, and more. Contains 12 practice-oriented topics including unprovoked venous thromboembolism: the search for a cause; approach to the patient with non-cardiac leg swelling; cold hands or feet: is it Raynaud's or not?; varicose veins: approaching assessment and management; and more.  Provides in-depth clinical reviews of vascular medicine, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.