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Most of the oral dosage forms possess several physiological
limitations such as variable gastrointestinal transit because of
variable gastric emptying leading to non-uniform absorption
profiles, incomplete drug release and shorter residence time of the
dosage form in the stomach. This leads to incomplete absorption of
drugs having absorption window especially in the upper part of the
small intestine, as once the drug passes down the absorption site,
the remaining quantity goes unabsorbed.Since many drugs are well
absorbed in the upper part of the gastrointestinal tract, such high
variability may lead to non-uniform absorption and makes the
bioavailability unpredictable. Hence, a beneficial delivery system
to control and prolong the gastric emptying time and can deliver
drugs in higher concentrations to the absorption site to show local
action in the stomach requires a specialized delivery system. So
the purpose of this study was to lengthen the stay of drug in its
favorable absorption area and prolonging the release of the drug by
formulating it into an effervescent gastro-retentive drug delivery
system.
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