This useful book reviews and analyzes the rigorous scientific, regulatory, and clinical testing and evaluation applied to the widely used food additive aspartame. In one compact volume you gain access to extensive information illustrating the increased recognition by regulatory agencies of the usefulness of human studies in evaluating new food additives. The Clinical Evaluation of a Food Additive: Assessment of Aspartame begins by describing the nuts and bolts of food additive safety evaluation in humans, including an insightful historical perspective of the development of good clinical practice guidelines. It provides the regulatory requirements for human research, as well as key elements for the design and conduct of human studies. The scientific and regulatory considerations of food additive safety are explored, including interesting descriptions of aspartame's key animal safety studies. In addition, the book reviews the medical postmarketing surveillance system developed for identifying and evaluating reports of aspartame's alleged adverse health effects. Through meticulous research and systematic clarity, The Clinical Evaluation of a Food Additive: Assessment of Aspartame provides work-saving, state-of-the-art examples to guide future testing and evaluation of tomorrow's food additives.

Case Studies in Allergic Disorders is designed for undergraduate and graduate students in immunology, medical students, and resident physicians. It describes the basic cellular and molecular mechanisms involved in the pathogenesis of commonly occurring allergic diseases and introduces the rationale for targeted treatment of allergy. Replicating the successful approach of Case Studies in Immunology, the book presents mechanisms of hypersensitivity through a selection of clinical cases that reinforce and extend the basic science. The cases are largely drawn from the records of Children's Hospital Boston. Linking the discussion of pathogenesis to actual clinical presentation establishes important connections between the bench and bedside. The book can be used as either a stand-alone text or asa companion to Janeway's Immunobiology and The Immune System.

Case Studies in Immunology, Sixth Edition, presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. The case histories illustrate essential points about the mechanisms of immunity and describe immunological problems seen in the clinic. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. Case Studies in Immunology highlights major common disorders of immunity, including hypersensitivity types I-IV, immune deficiencies, and autoimmune disorders. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the specific disorders. An end-of-case summary, questions, and discussion points conclude each case. Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway's Immunobiology, Eighth Edition. A marginal icon in Janeway's Immunobiology provides the reader with a link to the relevant Case Study, where the science is applied in a clinical setting. The book includes a total of 53 cases. The Sixth Edition is extensively revised and updated and includes ten new cases: * DiGeorge Syndrome * Hemophagocytic Lymphohistiocytosis * Chediak-Higashi Syndrome * Hyper IgE Syndrome * Ataxia Telangiectasia * Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome * Severe Congenital Neutropenia * Recurrent Herpes Simplex Encephalitis * Systemic Onset Juvenile Idiopathic Arthritis * Crohn's Disease