This volume constitutes the refereed proceedings of the 6th Multi-disciplinary International Workshop On Artificial Intelligence, MIWAI 2012, held in Ho Chi Minh City, Vietnam, in December 2012. The 29 revised full papers presented were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections in AI-GIS for climate change, computer vision, decision theory, e-commerce and AI, multiagent planning and learning, game theory, industrial applications of AI, multiagent systems and evolving intelligence, robotics and Web services.