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Niosomes are efficient carriers for controlled drug delivery, to
entrap hydrophilic drugs in the larger interior aqueous layer,
whereas, lipophilic drugs in the outer lipid bilayer. Since, the
niosomes are biodegradable and non toxic and hence, a good carrier
for targeting of therapeutic agents at the site of interest with
reduced systemic toxicity. Ketoprofen, non-steroidal
anti-inflammatory drug, is used for the treatment of rheumatoid
arthritis, osteoarthritis, degenerative joint conditions and
musculoskeletal disorders, involving long term therapy. Ketoprofen
has various side effects like gastritis, peptic ulcer and bleeding,
along with short biological half life (0.5-2 hrs) which calls for
frequent administration. Thus, a novel and controlled drug delivey
system need to be developed in order to increase its therapeutic
effects with reduced side effects.
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