Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how and why genomic surveillance may be applied. Drawing heavily from learnings during the Covid-19 pandemic, this book covers viral genome sequencing analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation types and speeds, RNA modulation of infection, pathogen diversity, and the role of co-infections and co-morbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent Covid-19 analysis, are discussed. Finally, authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines.

This valuable new book offers a new perspective on dendrimers that bridges the gap between basic research and applied nanomedicine. It explores the ultimate effectiveness of dendrimers in theranostics, a promising field that combines therapeutics and diagnostics into single multifunctional formulations used to affect therapy or treatment of a disease state. The authors examine the potential uses of dendrimers, which have proven their capabilities in local/systemic drug delivery, physical stabilization of the drug, solubility enhancement of the poorly soluble drugs, and gene delivery.

This valuable new book offers a new perspective on dendrimers that bridges the gap between basic research and applied nanomedicine. It explores the ultimate effectiveness of dendrimers in theranostics, a promising field that combines therapeutics and diagnostics into single multifunctional formulations used to affect therapy or treatment of a disease state. The authors examine the potential uses of dendrimers, which have proven their capabilities in local/systemic drug delivery, physical stabilization of the drug, solubility enhancement of the poorly soluble drugs, and gene delivery.

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.

In an uncertain future, a leader would rise to power in America. General George Rath is supremely charismatic, extraordinarily bold, and eerily intelligent. Rath's powerful aura would change the political and social structure of America forever. His meteoric rise to power would sweep the country up in a maelstrom of hysteria. But Colonel James Bradford had looked into Rath's eyes and had seen a frightening power that lurked inside. As he desperately attempts to uncover the mystery behind Rath's extraordinary power, he becomes entrapped in a horrifying web of betrayal and corruption. And although Bradford's daughter Alexandria is born at a terrible cost, she carries unimaginable powers of her own. She becomes engaged in a struggle to survive against terrifying enemies, as Rath's menacing shadow shrouds her future. With her own demons screaming inside of her, testing her will and the limits of her powers, Alexandria could be the only hope for a world that is spiraling toward unthinkable devastation. The three individuals must journey through searing landscapes of fear, chaos, and conflict, across the very boundaries of human existence on a collision course with the fate of the world...