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Pharmacokinetics and Toxicokinetic Considerations explains the
central principles, cutting-edge methodologies, and incipient
thought processes applied to toxicology research. As part of the
Advances in Pharmaceutical Product Development and Research series,
the book provides expert literature on dose, dosage regimen and
dose adjustment, medication errors, and approaches for its
prevention, the concept of pharmacotherapy, and managed care in
clinical interventions. It expounds on strategies to revamp the
pharmacokinetics of the drug and the factors affecting the
stability of drugs and their metabolites in biological matrices.
Finally, the book offers focused elaborations on various
bioanalytical methods for bioavailability and bioequivalence
assessment and integrates the wide-ranging principles and concepts
shared by toxicokinetics and pharmacodynamics as mutual crosstalk
rather than isolated observations. It will be helpful to
researchers and advanced students working in the pharmaceutical,
cosmetics, biotechnology, food, and related industries including
toxicologists, pharmacists, and pharmacologists.
Biopharmaceutics and Pharmacokinetics Considerations examines the
history of biopharmaceutics and pharmacokinetics. The book provides
a biopharmaceutics and pharmacokinetics approach to addressing
issues in formulation development and ethical considerations in
handling animals. Written by experts in the field, this volume
within the Advances in Pharmaceutical Product Development and
Research series deepens understanding of biopharmaceutics and
pharmacokinetics within drug discovery and drug development. Each
chapter delves into a particular aspect of this fundamental field
to cover the principles, methodologies and technologies employed by
pharmaceutical scientists, researchers and pharmaceutical
industries to study the chemical and physical properties of drugs
and the biological effects they produce.
The Future of Pharmaceutical Product Development and Research
examines the latest developments in the pharmaceutical sciences,
also highlighting key developments, research and future
opportunities. Written by experts in the field, this volume in the
Advances in Pharmaceutical Product Development and Research series
deepens our understanding of the product development phase of drug
discovery and drug development. Each chapter covers fundamental
principles, advanced methodologies and technologies employed by
pharmaceutical scientists, researchers and the pharmaceutical
industry. The book focuses on excipients, radiopharmaceuticals, and
how manufacturing should be conducted in an environment that
follows Good Manufacturing Practice (GMP) guidelines. Researchers
and students will find this book to be a comprehensive resource for
those working in, and studying, pharmaceuticals, cosmetics,
biotechnology, foods and related industries.
Toxicity and Toxicodynamics in Drug Research, Volume 1: Essentials
in Pharmatoxicology provides an overview on the essentials of
toxicology, risk assessment, and the mechanisms that might occur as
the result of toxicological and the potentially harmful action and
response of pharmaceuticals. Volume 1: Essentials in
Pharmatoxicology opens with an introduction to pharmatoxicology and
toxicology in drug research. It covers topics such as the types of
cellular responses to chemical toxicants, the mechanisms of drug
toxicity, and their relevance to pharmaceutical product
development. The book examines omics and computer-aided
technologies for mechanistic and predictive toxicology. The book
also covers state-of-art testing in the evaluation of detrimental
pathways, dose selection in toxicity studies, as well as expounds
on the role of regulatory agencies in toxicity studies. It covers
the mechanistic pathways of food toxicants and illustrates the
molecular mechanisms of the chemopreventive role of dietary
phytochemicals. There is also discussion on clinical interventions
such as pharmacotherapy and managed care strategies for acute
poisoning. This volume is a valuable resource to those learning
more about the drug development process related to toxicology and
those who want to get an update on newer concepts on the toxicology
aspect of drug research.
Drug Delivery Systems examines the current state of the field
within pharmaceutical science and concisely explains the history of
drug delivery systems, including key developments. The book
translates the physicochemical properties of drugs into drug
delivery systems administered via various routes, such as oral,
parenteral, transdermal and inhalational. Regulatory and product
development topics are also explored. Written by experts in the
field, this volume in the Advances in Pharmaceutical Product
Development and Research series deepens our understanding of drug
delivery systems within the pharmaceutical sciences industry and
research, as well as in chemical engineering. Each chapter delves
into a particular aspect of this fundamental field to cover the
principles, methodologies and technologies employed by
pharmaceutical scientists. This book provides a comprehensive
examination that is suitable for researchers and advanced students
working in pharmaceuticals, cosmetics, biotechnologies, and related
industries.
Basic Fundamentals of Drug Delivery covers the fundamental
principles, advanced methodologies and technologies employed by
pharmaceutical scientists, researchers and pharmaceutical
industries to transform a drug candidate or new chemical entity
into a final administrable drug delivery system. The book also
covers various approaches involved in optimizing the therapeutic
performance of a biomolecule while designing its appropriate
advanced formulation.
Dosage Form Design Parameters, Volume II, examines the history and
current state of the field within the pharmaceutical sciences,
presenting key developments. Content includes drug development
issues, the scale up of formulations, regulatory issues,
intellectual property, solid state properties and polymorphism.
Written by experts in the field, this volume in the Advances in
Pharmaceutical Product Development and Research series deepens our
understanding of dosage form design parameters. Chapters delve into
a particular aspect of this fundamental field, covering principles,
methodologies and the technologies employed by pharmaceutical
scientists. In addition, the book contains a comprehensive
examination suitable for researchers and advanced students working
in pharmaceuticals, cosmetics, biotechnology and related
industries.
Dosage Form Design Parameters, Volume I, examines the history and
current state of the field within the pharmaceutical sciences,
presenting key developments. Content includes drug development
issues, the scale up of formulations, regulatory issues,
intellectual property, solid state properties and polymorphism.
Written by experts in the field, this volume in the Advances in
Pharmaceutical Product Development and Research series deepens our
understanding of dosage form design parameters. Chapters delve into
a particular aspect of this fundamental field, covering principles,
methodologies and the technologies employed by pharmaceutical
scientists. In addition, the book contains a comprehensive
examination suitable for researchers and advanced students working
in pharmaceuticals, cosmetics, biotechnology and related
industries.
Biomaterials and Bionanotechnology examines the current state of
the field within pharmaceutical sciences and concisely explains the
history of biomaterials including key developments. Written by
experts in the field, this volume within the Advances in
Pharmaceutical Product Development and Research series deepens
understanding of biomaterials and bionanotechnology within drug
discovery and drug development. Each chapter delves into a
particular aspect of this fast-moving field to cover the
fundamental principles, advanced methodologies and technologies
employed by pharmaceutical scientists, researchers and
pharmaceutical industries to transform a drug candidate or new
chemical entity into a final administrable dosage form, with
particular focus on biomaterials and bionanomaterials. This book
provides a comprehensive examination suitable for researchers
working in the pharmaceutical, cosmetics, biotechnology, food and
related industries as well as advanced students in these fields.
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