This volume provides a serious examination of substance use prevention research and practice as components of the continuum from health promotion through to prevention and health care in sub-groups and in the general population. Extensive background chapters provide portals into the evolution of the field and the cutting edge research being conducted on the etiology, epidemiology, and genetics of substance use and abuse. The global nature and health burden of substance use and abuse incorporates assessments of the serious problems related to the prevention of legal substance use (i.e., alcohol and tobacco) and how lessons learned in those arenas may apply to the prevention of illicit substance use. Research and practice chapters detail a range of effective evidence-based programs, policies and practices and emerging prevention interventions from the literatures on the family and school contexts in addition to innovations involving mindfulness and the social media. Continued advancements in substance use prevention research, practice, training, and policy are projected. Included among topics addressed are: Progression of substance use to abuse and substance use disorders The tobacco prevention experience: a model for substance use prevention? Policy interventions: intended and unintended influences on substance use Qualitative methods in the study of psychoactive substance use Use of media and social media in the prevention of substance use Supporting prevention science and prevention research internationally The array of research accomplishments and real-world methods presented in Prevention of Substance Use merits the attention of a variety of researchers and practitioners, including public health professionals, health psychologists, and epidemiologists.