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This book offers an explanation of the specific ways that
biocatalysis outperforms chemical catalysis by: utilizing ambient
temperature and atmospheric pressure to minimize problems of
isomerization, racemization, and epimerization; employing microbial
cells and enzymes that can be immobilized and reused over many
cycles; and overexpressing enzymes for greater economy and
efficiency.
This book offers an explanation of the specific ways that
biocatalysis outperforms chemical catalysis by: utilizing ambient
temperature and atmospheric pressure to minimize problems of
isomerization, racemization, and epimerization; employing microbial
cells and enzymes that can be immobilized and reused over many
cycles; and overexpressing enzymes for greater economy and
efficiency.
Because enzyme-catalyzed reactions exhibit higher
enantioselectivity, regioselectivity, substrate specificity, and
stability, they require mild conditions to react while prompting
higher reaction efficiency and product yields. Biocatalysis in the
Pharmaceutical and Biotechnology Industries examines the use of
catalysts to produce fine chemicals and chiral intermediates in a
variety of pharmaceutical, agrochemical, and other biotechnological
applications. Written by internationally recognized scientists in
biocatalysis, the authors analyze the synthesis of chiral
intermediates for over 60 brand-name pharmaceuticals for a wide
range of drug therapies and treatments. From starting material to
product, the chapters offer detailed mechanisms that show chiral
intermediates and other by-products for each reaction-including
hydrolytic, acylation, halogenation, esterification,
dehalogenation, oxidation-reduction, oxygenation, hydroxylation,
deamination, transamination, and C-C, C-N, C-O bonds formation.
Cutting-edge topics include advanced methodologies for gene
shuffling and directed evolution of biocatalysts; the custom
engineering of enzymes; the use of microbial cells and isolated
biocatalysts; the use of renewable starting materials; and
generating novel molecules by combinatorial biocatalysis and
high-throughput screening. Focusing on industrial applications, the
book also considers factors such as bulk processes,
instrumentation, solvent selection, and techniques for catalyst
immobilization, reusability, and yield optimization throughout.
Biocatalysis in the Pharmaceutical and Biotechnology Industries
showcases the practical advantages and methodologies for using
biocatalysts to develop and produce chiral pharmaceuticals and fine
chemicals.
Because enzyme-catalyzed reactions exhibit higher
enantioselectivity, regioselectivity, substrate specificity, and
stability, they require mild conditions to react while prompting
higher reaction efficiency and product yields. Biocatalysis in the
Pharmaceutical and Biotechnology Industries examines the use of
catalysts to produce fine chemicals and chiral intermediates in a
variety of pharmaceutical, agrochemical, and other biotechnological
applications.
Written by internationally recognized scientists in
biocatalysis, the authors analyze the synthesis of chiral
intermediates for over 60 brand-name pharmaceuticals for a wide
range of drug therapies and treatments. From starting material to
product, the chapters offer detailed mechanisms that show chiral
intermediates and other by-products for each reaction-including
hydrolytic, acylation, halogenation, esterification,
dehalogenation, oxidation-reduction, oxygenation, hydroxylation,
deamination, transamination, and C-C, C-N, C-O bonds formation.
Cutting-edge topics include advanced methodologies for gene
shuffling and directed evolution of biocatalysts; the custom
engineering of enzymes; the use of microbial cells and isolated
biocatalysts; the use of renewable starting materials; and
generating novel molecules by combinatorial biocatalysis and
high-throughput screening.
Focusing on industrial applications, the book also considers
factors such as bulk processes, instrumentation, solvent selection,
and techniques for catalyst immobilization, reusability, and yield
optimization throughout. Biocatalysis in the Pharmaceutical and
Biotechnology Industries showcases the practical advantages and
methodologies for using biocatalysts todevelop and produce chiral
pharmaceuticals and fine chemicals.
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