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A simple, specific, accurate and precise stability indicating
reverse phase high performance liquid chromatographic (RP-HPLC)
method has been developed for the simultaneous estimation of
Aspirin and Isosorbide 5-mononitrate in bulk drug and its
pharmaceutical dosage form. A chromatographic separation was
achieved with reverse phase phenomenex(r) Luna 5u C18 (2) 100A (250
x 4.60 mm) column in an isocratic mode at ambient temperature. The
mobile phase consisting of water: methanol: acetonitrile (55:28:17%
v/v/v) at a flow rate of 1 ml/min. The eluents were monitored at
217 nm. The retention times of Aspirin and Isosorbide 5-mononitrate
were found to be 2.05 0.056 min and 4.27 0.016 min respectively.
The regression analysis revealed linearity in the concentration
range of 1-10 ug/ml and 1-10 ug/ml for Aspirin and Isosorbide
5-mononitrate respectively. The method was validated in terms of
linearity, accuracy, precision, limit of detection (LOD), limit of
quantification (LOQ) in accordance with ICH guide lines. The
results of the study showed that the developed method is simple,
precise and accurate, and therefore suitable for routine analysis
of these drugs in pharmaceutical dosage for
Whenever we hear the term "Steroids" we always interprete it as
just a mass gaining, body building substances. In earlier days
atheletes use to eat raw testicles to enhance their performance in
sports activities and now-a-days atheletes are using steroids to
enhance their performance in sports activities (doping). So, their
current image is negatively builded as abusable drugs. These
steroids are organic compounds which are chemically altered to
mimic hormone testosterone, these are called as "Synthetic
steroids." "Natural Steroids," are the organic compounds which are
NOT chemically altered, that mimics hormones, and obviously the
hormone it mimics is testosterone. Natural Steroids are involved in
a wide range ofphysiologicprocesses, includingstress response,
immune response, carbohydrate metabolism, proteincatabolism,
bloodelectrolyte levels, and in the regulation ofinflammation, and
behavior."
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