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Part I. Micro and Nanoscale Biosensors and Materials: Biosensors
and Biochips.- Cantilever Assays: A Universal Platform for
Multi-plexed Label-Free Bioassays.- An On-chip Artificial Pore For
Molecular Sensing.- Cell Based Chemical Sensing Technologies.-
Fabrication issues of Biomedical Micro Devices.- Intelligent
Polymeric Networks in Biomolecular Sensing.- Part II Processing and
Integrated Systems: A Multi-Functional Micro Total Analysis System
( TAS) Platform for Transport and Sensing of Biological Fluids
using Microchannel Parallel Electrodes.- Dielectrophoretic Traps
for Cell Manipulation.- BioMEMS for Cellular Manipulation and
Analysis.- Implantable Wireless Microsystems.- Microfluidic
Tectonics: An integrated organic autonomous platform.- AC
Electrokinetic Stirring and Focusing of Nanoparticles.- Part III.
Micro-fluidics and Characterization: Particle Dynamics in a
Dielectrophoretic Microdevice.- Microfluidics Simulations I.-
Modeling Electroosmotic Flow in Nanochannels.- Nano-Particle Image
Velocimetry: A Near-Wall Velocimetry Technique with Submicron
Spatial Resolution.- Optical MEMS-Based Sensor Development with
Applications to Microfluidics.- Vascular Cell Responses to Fluid
Shear Stress.
Nanopores are nanometer scale holes formed naturally by proteins or
cells, and can be used for a variety of applications, including
sequencing DNA and detecting anthrax. They can be integrated into
artificially constructed encapsulated cells of silicon wafers while
allowing small molecules like oxygen, glucose and insulin to pass,
while keeping out large system molecules. "Nanopores: Sensing and
Fundamental Biological Interactions" examines the emerging research
directions surrounding nanopores such as genome sequencing and
early disease detection using biomarker identification. Covering
the applications of nanopores in genetics, proteomics, drug
discovery, early disease detection and detection of emerging
environmental threats, it is a must-have book for
biomedicalengineers and research scientists.
Nanopores are nanometer scale holes formed naturally by proteins
or cells, and can be used for a variety of applications, including
sequencing DNA and detecting anthrax. They can be integrated into
artificially constructed encapsulated cells of silicon wafers while
allowing small molecules like oxygen, glucose and insulin to pass,
while keeping out large system molecules. "Nanopores: Sensing and
Fundamental Biological Interactions" examines the emerging research
directions surrounding nanopores such as genome sequencing and
early disease detection using biomarker identification. Covering
the applications of nanopores in genetics, proteomics, drug
discovery, early disease detection and detection of emerging
environmental threats, it is a must-have book for
biomedicalengineersand research scientists."
Less than twenty years ago photolithography and medicine were total
strangers to one another. They had not yet met, and not even
looking each other up in the classi?eds. And then, nucleic acid
chips, micro?uidics and microarrays entered the scene, and rapidly
these strangers became indispensable partners in biomedicine.
Asrecentlyastenyearsagothenotionofapplyingnanotechnologytothe?ghtagainstd-
ease was dominantly the province of the ?ction writers. Thoughts of
nanoparticle-vehicled
deliveryoftherapeuticalstodiseasedsiteswereanexerciseinscienti?csolitude,andgrounds
for questioning one's ability to think "like an established
scientist". And today we have nanoparticulate paclitaxel as the
prime option against metastatic breast cancer, proteomic
pro?lingdiagnostictoolsbasedontargetsurfacenanotexturing,nanoparticlecontrastagents
for all radiological modalities, nanotechnologies embedded in
high-distribution laboratory equipment, and no less than 152 novel
nanomedical entities in the regulatory pipeline in the US alone.
Thisisatransformingimpact,byanymeasure,withclearevidenceoffurtheracceleration,
supported by very vigorous investments by the public and private
sectors throughout the world. Even joining the dots in a most
conservative, linear fashion, it is easy to envision scenarios of
personalized medicine such as the following: patient-speci?c
prevention supplanting gross, faceless intervention strategies;
early detection protocols identifying signs of developing disease
at the time when the disease is most easily subdued; personally
tailored intervention strategies that are so routinely and
inexpensively realized, that access to them can be secured by
everyone; technologies allowing for long lives in the company of
disease, as good neighbors, without impairment of the quality of
life itself.
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