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Great advances were made in the pharmacologic-based treatment of
cancer in prior decades. However, despite a marked increase in our
understanding ofcell and molecular mechanisms underlying the
neoplastic process, therapy for advanced disease remains limited.
While the reasons for this are many, it is generally accepted that
advanced neoplasms contain a relatively large number of genetic and
molecularalterations contributingto the maintenanceofthe neoplastic
process. Such a situation precludes easy pharmacologic
intervention. However, our ability to detect cancer at an earlier
stage, coupled with our increased understandingofcarcinogenesis,
are propellingboth basic and clinical scientiststo pursue early
intervention/chemopreventive approaches. This is based upon the
notion that fewer molecularaberrations are presentearlyon
inthedisease process. It also takes advantage ofthe fact that
advances in both technology, and in the field ofcancer biology,
coupled with a heightened vigilance, have increased our ability to
detect early disease more readily. The chemopreventive approach is
highly attractive for a number ofreasons. First, treatment
ofpre-neoplastic, or early neoplastic, lesions would prevent the
significant mobility and mortality associated with advanced
neoplastic disorders.
Great advances were made in the pharmacologic-based treatment of
cancer in prior decades. However, despite a marked increase in our
understanding ofcell and molecular mechanisms underlying the
neoplastic process, therapy for advanced disease remains limited.
While the reasons for this are many, it is generally accepted that
advanced neoplasms contain a relatively large number of genetic and
molecularalterations contributingto the maintenanceofthe neoplastic
process. Such a situation precludes easy pharmacologic
intervention. However, our ability to detect cancer at an earlier
stage, coupled with our increased understandingofcarcinogenesis,
are propellingboth basic and clinical scientiststo pursue early
intervention/chemopreventive approaches. This is based upon the
notion that fewer molecularaberrations are presentearlyon
inthedisease process. It also takes advantage ofthe fact that
advances in both technology, and in the field ofcancer biology,
coupled with a heightened vigilance, have increased our ability to
detect early disease more readily. The chemopreventive approach is
highly attractive for a number ofreasons. First, treatment
ofpre-neoplastic, or early neoplastic, lesions would prevent the
significant mobility and mortality associated with advanced
neoplastic disorders.
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