This book constitutes the refereed proceedings of the 15th International Conference on Pervasive Computing Technologies for Healthcare, Pervasive Health 2021, held in December 2021. Due to COVID-19 pandemic the conference was held virtually. The 28 full and 7 short papers were selected from 74 submissions and are organized in 3 main tracks: hospitality and community care, homecare and medical education. The COVID 19 pandemic was challenging all dimensions of Pervasive Health (PH) and traditional ways of monitoring, diagnosing, treating and communicating changed dramatically.