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There is no doubt that nowadays, biology benefits greatly from
mathematics. In particular, cellular biology is, besides population
dynamics, a field where tech niques of mathematical modeling are
widely used. This is reflected by the large number of journal
articles and congress proceedings published every year on the
dynamics of complex cellular processes. This applies, among others,
to metabolic control analysis, where the number of articles on
theoretical fundamentals and experimental applications has
increased for about 15 years. Surprisingly, mono graphs and
textbooks dealing with the modeling of metabolic systems are still
exceptionally rare. We think that now time is ripe to fill this
gap. This monograph covers various aspects of the mathematical
description of enzymatic systems, such as stoichiometric analysis,
enzyme kinetics, dynamical simulation, metabolic control analysis,
and evolutionary optimization. We believe that, at present, these
are the main approaches by which metabolic systems can be analyzed
in mathematical terms. Although stoichiometric analysis and enzyme
kinetics are classical fields tracing back to the beginning of our
century, there are intriguing recent developments such as detection
of elementary biochemical syn thesis routes and rate laws for the
situation of metabolic channeling, which we have considered worth
being included. Evolutionary optimization of metabolic systems is a
rather new field with promising prospects. Its goal is to elucidate
the structure and functions of these systems from an evolutionary
viewpoint."
There is no doubt that nowadays, biology benefits greatly from
mathematics. In particular, cellular biology is, besides population
dynamics, a field where tech niques of mathematical modeling are
widely used. This is reflected by the large number of journal
articles and congress proceedings published every year on the
dynamics of complex cellular processes. This applies, among others,
to metabolic control analysis, where the number of articles on
theoretical fundamentals and experimental applications has
increased for about 15 years. Surprisingly, mono graphs and
textbooks dealing with the modeling of metabolic systems are still
exceptionally rare. We think that now time is ripe to fill this
gap. This monograph covers various aspects of the mathematical
description of enzymatic systems, such as stoichiometric analysis,
enzyme kinetics, dynamical simulation, metabolic control analysis,
and evolutionary optimization. We believe that, at present, these
are the main approaches by which metabolic systems can be analyzed
in mathematical terms. Although stoichiometric analysis and enzyme
kinetics are classical fields tracing back to the beginning of our
century, there are intriguing recent developments such as detection
of elementary biochemical syn thesis routes and rate laws for the
situation of metabolic channeling, which we have considered worth
being included. Evolutionary optimization of metabolic systems is a
rather new field with promising prospects. Its goal is to elucidate
the structure and functions of these systems from an evolutionary
viewpoint."
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