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Indole derivatives are the most common heterocycle compounds
present in nature, for this reason, they have been referred to as
'privileged structures'. In fact, many approved drugs - and natural
products - belong to this family. Among indole derivatives,
oxindoles have a structural complexity, which have stimulated
generations of synthetic chemists to design strategies for
assembling these structures, and their enantioselective synthesis
is still growing.This book proposes to describe the known
enantioselective syntheses of oxindole derivatives. It is divided
in six chapters each referring to a specific class of asymmetric
oxindole derivatives. After the introduction, Chapter 2 describes
all-carbon spirooxindoles; Chapter 3, open chain
3,3-dialkyloxindoles; Chapter 4, 3-substituted-3-aminooxindoles;
Chapter 5, 3-substituted-3-hydroxyoxindoles; Chapter 6,
3-hetero-3-substituted oxindoles. It will be a useful tool for
synthetic chemists, who assemble total synthesis of natural
products, as well as for drug discovery chemists either in academic
or in industry R&S laboratories.
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