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This conference, dedicated to the etiology and treatment of
motility disor ders in spermatozoa and male sterility, attracted
some of the finest investiga tors in the field. Standards were
immensely high throughout, and discussions were meaningful and
detailed. Analyses on disorders in sperm motility de mand a
broad-based approach, involving cytologists, geneticists,
andrologists, and embryologists, because the topic has many
clinical and scientific over tones. Human spermatozoa are at the
mercy of so many factors as they form and mature in the testis and
epididymis. Their survival and fundamental char acteristics are
essential for fertilization, and the male genome imposes its
influence on the embryo as it becomes active in male pronuclei very
soon after sperm entry into the oocyte. All of these fundamental
aspects of sperm biology demanded a broad breadth of topics in the
symposium. The opening session quickly got down to fundamentals
with contributions from J.-L. Gatti, J.G. Alvarez, C. Gagnon, and
H. Breitbart. They discussed the mechanism and regulation of
motility, the metabolic strategy of human spermatozoa, the effects
of exogenous fac tors such as antibodies, infections, and toxins,
and finally the role of intracel lular calcium on sperm motility.
To these topics, the postcoffee session on the first morning
described the genetics of motility disorders and the etiology and
management of necrozoospermia. The excellent presentation provided
the background detail of the symposium and opened the way for the
discus sion of various clinical aspects of the topic.
This volume is the proceedings of the International Symposium on
Male Sterility for Motility Disorders, held in Paris, January
30-31, 1998. The internationally recognized faculty present the
latest research on etiologic factors and treatment of male
sterility for motility disorders, including the etiology of
immobile sperm; therapeutic possibilities for immotile sperm; ICSI
option; testicular sperm, physiological and pathological aspects
and retrieval; and conceptus quality in ICSI and ethical problems
with ART.
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