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This is the first book published that discusses state of the art
research regarding AMH in human reproduction and medicine. This
unique and vital protein impacts a variety of fundamental processes
within the ovaries and testes. Since its discovery in 1947, every
medical student has learned about the role AMH plays in embryonic
sexual differentiation. However, the last fifteen years have
witnessed AMH emerge from the bench to the bedside, from a
scientific curiosity to a useful diagnostic tool with clinical
utility and therapeutic applications. In female reproduction, AMH
has undergone a virtual renaissance after it was discovered in the
human ovarian follicle and later to reflect ovarian reserve. Since
that time, much has been learned regarding the role of AMH in
female reproductive aging and a number of other gynecological
conditions. This is reflected by a number of peer-reviewed
publications on AMH in human adult females, which has increased
exponentially over the past three decades. It is only in the last
decade that AMH has become an important marker of ovarian response,
guiding clinical decision making in assisted reproductive
technology (ART) as well as a useful aid in the diagnosis of
polycystic ovarian syndrome (PCOS). In male reproduction, AMH has
become a diagnostic tool in the complex evaluation of infants with
intersex conditions, including ambiguous genitalia and
cryptorchidism. The chapters of this book bring together
experienced investigators with a variety of research interests in
different aspects of AMH. Each contributor has conducted clinical,
translational and/or basic research in the field of AMH. Each has
an appreciation of what is known and an aspiration for solving what
remains to be discovered. A better understanding of AMH
pathophysiology may lead to the development of pharmacological
treatments using AMH agonists and/or antagonists for a host of
reproductive challenges. These include: the possible retardation of
ovarian aging and menopause; a chemoprotectant for fertility
preservation prior to chemotherapy; a tool to better control
ovarian response to ART and/or to mitigate the deleterious effects
of polycystic ovary syndrome; and a treatment for endometriosis,
adenomyosis and/or endometrial and ovarian cancers. This book
enables the reader to review the past, understand the present and
consider the future of this multifaceted protein in the fields of
reproductive medicine and gynecology.
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