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Annual Report on Medicinal Chemistry series, highlights new
advances in the field with this new volume presenting interesting
chapters. Each chapter is written by an international board of
authors.
Kinase inhibition remains an area of significant interest, and
growing importance, across academia and the pharmaceutical
industry. There are now many marketed drugs that target kinases and
a significant number of compounds are currently in various stages
of clinical development. This book is a forward-looking analysis of
a number of key areas for kinase inhibition in the coming years and
builds on the first volume. This includes topics such as screening
approaches to target kinases along with different modes of
inhibition such as allosteric and covalent. Novel approaches such
as macrocyclisation are considered along with how the properties of
kinase inhibitors have evolved, including the potential for brain
penetration. Recent areas of great importance also covered include
cutting edge molecular modelling approaches and the importance of
kinase mutations. The evolving biology of kinases has also resulted
in increased interest in the immuno-oncology area and also
pseudokinases as a target family. As with the first volume the book
finishes with a forward looking view of how research against this
fascinating target class may evolve.
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