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First published in 1991, this book covers three major areas
essential to in vivo biochemical studies with PET and SPECT:
synthesis of radiopharmaceuticals, biological modeling, and
clinical applications. The book emphasizes advances in the
synthesis of radiopharmaceuticals used in PET and SPECT studies of
brain flow and oxidatative metabolism, in addition to biological
modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose
models are discussed, as well as models used in the quantitation of
brain receptors. Other topics include a possible model for
converting 6-[18F] fluorodopa images into the quantitative rate of
dopamine synthesis, evaluations of technetium- and iodine-labeled
blood flow tracers, and possibilities for using SPECT to measure
other pathophysiological variables. This book will be a valuable
reference source to students and specialists interested in these in
vivo measurements.
First published in 1991, this book covers three major areas
essential to in vivo biochemical studies with PET and SPECT:
synthesis of radiopharmaceuticals, biological modeling, and
clinical applications. The book emphasizes advances in the
synthesis of radiopharmaceuticals used in PET and SPECT studies of
brain flow and oxidatative metabolism, in addition to biological
modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose
models are discussed, as well as models used in the quantitation of
brain receptors. Other topics include a possible model for
converting 6-[18F] fluorodopa images into the quantitative rate of
dopamine synthesis, evaluations of technetium- and iodine-labeled
blood flow tracers, and possibilities for using SPECT to measure
other pathophysiological variables. This book will be a valuable
reference source to students and specialists interested in these in
vivo measurements.
An Advanced Study Institute on Ultrasonics in Medical Diagnosis was
held in Milan, Italy, from 10 to 15 June 1974. This ASI was of a
short five-day duration and limited to cardiac diagnosis by ultra
sound only. Since that time, the field of diagnostic imaging in
medicine has literally exploded with new and improved means of
medical diagnosis such as computed tomography, microwaves, nuclear
magnetic resonance and other sophisticated techniques. These
developments have enabled medical practitioners to make diagnoses
with a minimum of danger to the patient, and a maximum of accuracy
never before possible, and represent a multi-quantum advance over
the early state-of-the-art presented at the 1974 ASI. Since then,
several meetings have taken place on these individual topics to
bring together experts who presented their latest research results,
but none have discussed the entire field of diagnostic imaging in
medicine in one meeting nor have they had the teaching character of
an Advanced Study Institute. The art and science of medicine have
been altered repeatedly during the eight year interval since the
last ASI. Today's clinician must be part technologist and must be
enough of an investigator to understand and appreciate the
scientific method. The current complex advances in instrumentation
and pharmacology have had a marked effect on how medicine is
practiced. There was, therefore, an urgent need to bring the entire
field of imaging in medicine to one teaching podium where the many
advances of the last six or seven years could be reviewed.
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