NASA has developed an experimental flight payload (referred to as the Space Communication and Navigation (SCAN) Test Bed) to investigate software defined radio (SDR) communications, networking, and navigation technologies, operationally in the space environment. The payload consists of three software defined radios each compliant to NASAs Space Telecommunications Radio System Architecture, a common software interface description standard for software defined radios. The software defined radios are new technology developments underway by NASA and industry partners launched in 2012. The payload is externally mounted to the International Space Station truss to conduct experiments representative of future mission capability. Experiment operations include in-flight reconfiguration of the SDR waveform functions and payload networking software. The flight system will communicate with NASAs orbiting satellite relay network, the Tracking and Data Relay Satellite System at both S-band and Ka-band and to any Earth-based compatible S-band ground station. The system is available for experiments by industry, academia, and other government agencies to participate in the SDR technology assessments and standards advancements.