The sensory hair cells in the inner ear and vestibular system convert mechanical stimuli, sound and motion into neural activity that is responsible for the sensations of hearing, motion and head position. In mammals, the loss of hair cells from acoustic overstimulation, ototoxic drugs and aging is irreversible, leading to a permanent loss of function. However, it is now clear that hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. Moreover, partially damaged hair cells can undergo self-repair or be protected from traumatic insults by external compounds.This volume provides a comprehensive survey of what is currently known about the regeneration, repair and protection of sensory hair cells and subsequent recovery of function in the auditory and vestibular system. The aim is to provide graduate students, postdoctoral fellows, clinicians and scientists in related disciplines with the biological bases of hair cells and with an understanding of the factors that contribute to their regeneration and repair.

In September 1985, NATO sponsored an Advanced Study WOl'kshop entitled, "Noise-Induced Hearing Loss: Basic and Applied Aspects." Tne meeting was held in a mountain retreat near Lucca, Italy and was attended by scientists, clinicians, and public officials from 12 countries. This was the third in a series of such conferences organized by the authors. The first two were supported by the United States National Institute of Occupational Safety and Health; their proceedings were published as "The Effects of Noise on Hearing" in 1976 and "New Perspectives on Noise-Induced Hearing Loss" in 1982. The Organizing Committee approached NATO because it was felt that the problem of noise was common to all industrialized countries and was an especially serious problem for the military. Thus, the NATO sponsorship and the Italian site of the meeting were part of the Organizing Committee's plan to obtain an international and thorough repr'esentation on the problem of noise-induced hearing loss. The NATO meeting and proceedings followed the format of the previous two symposia with an initial focus on the anatomical and physiological disturbances resulting from noise-induced hearing loss. This was followed by sections devoted to studies of a more applied nature involving general auditory performance in noise, issues associated with the establishment of noise-exposure criteria, nonauditory effects of noise, and the interaction of noise with other agents.

Not male pattern baldness, but the loss of sensory hair, is a very serious topic. Sensory hair cells convert sound and motion into our sense of hearing, movement, and head position. In mammals, the loss of hair cells is irreversible. Or is it? Hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. This book provides a comprehensive survey of the regeneration of sensory hair cells.