This volume contains the proceedings of the 14th Colloque Medecine et Recher- che of the Fondation Ipsen pour la Recherche Therapeutique devoted to Alzhei- mer's disease. It was held in Paris on May 25, 1998 and dedicated to the epidemi- ological study of this dementia, a very important issue because the incidence and prevalence of Alzheimer's disease rise exponentially with age. Epidemiological findings not only confirm dementia as a major challenge for the coming years but also contribute defining risk factors, predicting and may be preventing this disease. All these issues have been tackled at the meeting in Paris and in the present book. Y. C. Contents The World-Wide Impact of Dementia. Projections of Prevalance and Costs R. Katzmann and P. J. Fox ...1 Predicting Who Will Develop Alzheimer's Disease R. Mayeux ...19 Genetic Factors in Early-and Late-Onset Alzheimer's Disease J. Tol, A. J. e. Slooter, and e. M. Van Duijn ...33 Heterogeneity in Alzheimer's Disease: Implications for Epidemiology T. S. Radebaugh, M. Ganguli, and Z. S. Khachaturian ...41 The Epidemiology of Alzheimer's Disease: The Role of Estrogen in Reducing Risk v. w. Henderson...4 9 Inflammation, Anti-Inflammatory Drugs and Alzheimer's Disease C. H. Kawas ...65 Socio-Demographic Risk Factors for Dementia and Alzheimer's Disease in the Paquid Study J. P. Dartigues, e. Helmer, and L. Letenneur ...73 Vascular Disease and Vascular Risk Factors and Dementia M. M. B. Breteler, M. e. Bots, A. Ott, and A. Hofman...79 Alzheimer's Disease: A Review of Cross-Cultural Studies H. C. Hendrie...

This concise but wide-ranging handbook reviews the epidemiology of neurological disease and the treatment and prognosis of all major diseases of the nervous system. Part One offers essential guidance for clinicians to quantitative methods in research, including genetic epidemiology, decision analysis, meta-analysis, outcomes research, and survival analysis. Thus it provides a good understanding of the evidence underlying clinical management. The second part is devoted to individual neurological diseases, covering etiology, diagnosis, prognosis, interventions, and implications for clinical practice. With contributions from leading international authorities, this book is an invaluable guide to clinical decision-making for neurologists and others involved in the management of neurological disease.