Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology and therapeutic applications. The book also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. It begins with an overview of fundamental glycobiology followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research. Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis.

The "great dichotomy" between left and right has been a feature of pluralist politics since its emergence in modern times. Left and right are also central to the understanding of the political history of the twentieth century and may be gaining renewed visibility in the context of the current economic crisis, both in Europe and beyond. Should scholars think, once again, with and within the dichotomy, or can they think better beyond its strictures? The contributions to this volume provide answers to these and other questions in ways that are theoretically sound and empirically informed.