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This authoritative volume contains 179 chapters by international
experts on recent developments in our understanding of amyloid
proteins, protein folding disorders, and new and proposed clinical
trials in amyloidosis. Topics include detection and
characterization techniques; biological functions; genetics;
disorders, diagnosis, and treatments, including organ transplants
and drug therapies; results from extensive clinical studies; and
epidemiology. This is a valuable resource for clinicians who care
for patients with systemic and localized forms of amyloidosis, and
for researchers in biochemistry, neurobiology, and cell biology.
Plasma cell dyscrasias are common causes of peripheral neuropathy.
Peri- pheral neuropathy may be the first manifestation of multiple
myeloma, amyloidosis, or monoclonal gammopathy of undetermined
significance (MGUS). Peripheral neuropathy occurs in more than
one-half of patients with osteosclerotic myeloma. The hematologic
disorders are such an important association with peripheral
polyneuropathy that, for the last decade, we have obtained a
metastatic bone survey and immunoelectrophoresis of serum and a
24-hour urine specimen on all patients older than 40 years with
undiagnosed peripheral neuropathy. This textbook on
polyneuropathies and plasma cell dyscrasia is welcome, because the
subject is of considerable medical importance and because the
authors are expert in these disorders. Kelly's studies have shown
that a systematic search for monoclonal proteins in plasma and
urine among patients with neuropathy of unknown cause increases
diagnostic yield. Latov's studies have focused on the role of
myelin associated glycoproteins (MAG) in the induction of
neuropathy. Kyle, director of the Special Protein Laboratory at
Mayo Clinic, brings a broad clinical and laboratory perspective and
experi- ence. The timing of the textbook is just right, because
there is much new information which needs to be summarized.
Plasma cell dyscrasias are common causes of peripheral neuropathy.
Peri- pheral neuropathy may be the first manifestation of multiple
myeloma, amyloidosis, or monoclonal gammopathy of undetermined
significance (MGUS). Peripheral neuropathy occurs in more than
one-half of patients with osteosclerotic myeloma. The hematologic
disorders are such an important association with peripheral
polyneuropathy that, for the last decade, we have obtained a
metastatic bone survey and immunoelectrophoresis of serum and a
24-hour urine specimen on all patients older than 40 years with
undiagnosed peripheral neuropathy. This textbook on
polyneuropathies and plasma cell dyscrasia is welcome, because the
subject is of considerable medical importance and because the
authors are expert in these disorders. Kelly's studies have shown
that a systematic search for monoclonal proteins in plasma and
urine among patients with neuropathy of unknown cause increases
diagnostic yield. Latov's studies have focused on the role of
myelin associated glycoproteins (MAG) in the induction of
neuropathy. Kyle, director of the Special Protein Laboratory at
Mayo Clinic, brings a broad clinical and laboratory perspective and
experi- ence. The timing of the textbook is just right, because
there is much new information which needs to be summarized.
This authoritative volume contains 179 chapters by international
experts on recent developments in our understanding of amyloid
proteins, protein folding disorders, and new and proposed clinical
trials in amyloidosis. Topics include detection and
characterization techniques; biological functions; genetics;
disorders, diagnosis, and treatments, including organ transplants
and drug therapies; results from extensive clinical studies; and
epidemiology. This is a valuable resource for clinicians who care
for patients with systemic and localized forms of amyloidosis, and
for researchers in biochemistry, neurobiology, and cell biology.
Due to major advances in understanding the biology and pathogenesis
of the disease, the management of multiple myeloma is changing
rapidly. New diagnostic and prognostic criteria have been
introduced, and treatment options are multiplying with high-dose
chemotherapy regimens, stem cell transplants, and the development
of novel agents and immune-based strategies that target tumor cells
directly. This book is aimed at the practitioner who is looking to
put these advances into clinical context. It will serve as an
up-to-date resource for treatment of myeloma and related disorders.
Chapters are written by international authorities and contain color
photos, diagrams, and algorithms outlining preferred treatment
strategies. Relevant scientific information is integrated
throughout, but the focus here is on providing practical
therapeutic guidance for oncologists and hematologists caring for
myeloma patients. The book covers all myeloma subtypes and related
disorders, including amyloidosis, Waldenstrom macroglobulinemia,
plasmacytoma, MGUS, and POEMS syndrome.
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