The prevailing reality is that good educators do the tangible things well. Great educators also do the intangible things well. One-on-One education is packed to the brim with intangible moments that we can identify, hone in on, and master. When educators or parents work with students at a One-on-One level, challenges often arise. Knowing a subject does not necessarily mean one can teach it, let alone teach it effectively and inspirationally. So many factors, strategies, and actions combine to make exceptional One-on-One instruction. "One-on-One 101" is the authoritative roadmap to mastering the art of individualized instruction. The original learning form is One-on-One, beginning when a child first looks to a parent for guidance. The most coveted learning form is also One-on-One, as schools struggle with increasing class sizes and move towards newer models of teaching, such as "flipped" and blended learning. These emerging models demand a comprehensive definition of what transcendent One-on-One learning looks like and how best to implement it. Individualized instruction is highly sought after for the personalized attention it offers, but it remains elusive for so many people due to its high costs, complexity, and impracticality. What is the "secret sauce" that goes into prospering within this realm of education? The precise formula is known by a select few but direly needed by so many. "One-on-One 101" serves to empower anyone to be a successful One-on-One expert. Critical bedrocks of ideal One-on-One dynamics include using specific socio-emotional cues, leveraging praise without falling back on faulty longstanding conventions, meaningfully connecting with students, and putting into play a wide array of teaching tricks, such as appropriately timing specific verbal phrases, avoiding pitfalls, and permanently ending student shutdown. Inspired individualized instruction is a true art form, and "One-on-One 101" stands as the definitive guidebook for mastering this art.