This thorough volume explores recent advances that have revolutionized the field of precision oncology. The chapters, contributed by experts in the areas of cancer systems and integrative biology, provide hands-on guidance toward developing tools to monitor spatial and temporal changes in tumors, tracking tumor markers in blood, and ultimately developing precision medicine to combat cancer in real time. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that ensures successful results.  Authoritative and informative, Cancer Systems and Integrative Biology serves as an invaluable resource for researchers, pharmaceutical scientists, and oncologists interested in expanding their knowledge base in the current developments in cancer research.

This book uses Ludwig Wittgenstein's philosophical methodology to solve a problem that has perplexed thinkers for thousands of years: 'how come (abstract) mathematics applies so wonderfully well to the (concrete, physical) world?' The book is distinctive in several ways. First, it gives the reader a route into understanding important features of Wittgenstein's writings and lectures by using his methodology to tackle this long-standing and seemingly intractable philosophical problem. More than this, though, it offers an outline of important (sometimes little-known) aspects of the development of mathematical thought through the ages, and an engagement of Wittgenstein's philosophy with this and with contemporary philosophy of mathematics on its own terms. A clear overview of all this in the context of Wittgenstein's philosophy of mathematics is interesting in its own right; it is also just what is needed to solve the problem of mathematics and world.