Exploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders. Compiles previously unpublished data from the first extensive scientific investigations of Xolair! IgE and Anti-IgE Therapy in Asthma and Allergic Disease -reviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe -offers novel methods for the design and formulation of monoclonal antibodies -discusses the use of allergen bronchoprovocation to identify the characteristics and efficacy of new antiasthma and antiallergy medications -examines the role of IgE in food and parasitic allergies and covers -the pathogenesis of atopic dermatitis and urticaria -novel strategies to target mast cells and basophils -murine models of allergic pulmonary inflammation -the pathophysiology of allergic rhinitis Supplemented with nearly 2000 contemporary references to facilitate further study, IgE and Anti-IgE Therapy in Asthma and Allergic Disease is an in-depth and timely source for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medicalschool students in these disciplines.