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In the dark recesses of Tyria, elder dragons have awoken from
millennial slumbers. First came Primordus, which stirred in the
Depths forcing the asura to flee to the surface. Half a century
later, Jormag awoke and drove the norn from the frozen climes of
the Northern Shiverpeaks, corrupting sons and brothers along the
way. A generation later, Zhaitan arose in a cataclysmic event that
reshaped a continent and flooded the capital of the human nation of
Kryta. The races of Tyria stand on the edge of destiny. Heroes have
battled against dragon minions, only to be corrupted into service
of the enemy. Armies have marched on the dragons and been swept
aside. The dwarves sacrificed their entire race to defeat a single
dragon champion. The age of mortals may soon be over. This is a
time for heroes. While the races of Tyria stand apart, six heroic
individuals will come together to fight for their people: Eir, the
norn huntress with the soul of an artist; Snaff, the asuran genius,
and his ambitious assistant Zojja; Rytlock, the ferocious charr
warrior in exile; Caithe, a deadly sylvari with deep secrets; and
Logan, the valiant human guardian dealing with divided loyalties.
Together they become Destiny's Edge. Together they answer the call.
But will it be enough?
The purpose of the first four volumes of the Handbook of Genetics
is to bring together collections of relatively short, authoritative
essays or an notated compilations of data on topics of significance
to geneticists. Many of the essays will deal with various aspects
of the biology of certain species or species groups selected
because they are favorite subjects for genetic investigation in
nature or the laboratory. Often there will be an encyclo pedic
amount of information available on such species, with new papers
appearing daily. Most of these will be written for specialists in a
jargon that is bewildering to a novice, and sometimes even to a
veteran geneticist working with evolutionarily distant organisms.
For such readers what is needed is a written introduction to the
morphology, life cycle, reproductive behavior, and culture methods
for the species in question. What are its particular advantages
(and disadvantages) for genetic study, and what have we learned
from it? Where are the classic papers, the key bibliogra phies, and
how does one get stocks of wild type or mutant strains? Lists
giving the symbolism and descriptions for selected mutants that
have been retained and are thus available for future studies are
provided whenever possible. Genetic and cytological maps, mitotic
karyotypes, and haploid DNA values are also included when
available. The chapters in this volume deal with invertebrate
species that are favorites of geneticists. Attempts to obtain a
chapter dealing with the genetics of Caenorhabditis elegans proved
unsuccessful.
Many modern geneticists attempt to elucidate the molecular basis of
phenotype by utilizing a battery of techniques derived from
physical chemistry on subcellular components isolated from various
species of organisms. Volume 5 of the Handbook of Genetics provides
explanations of the advantages and shortcomings of some of these
revolutionary tech niques, and the nonspecialist is alerted to key
research papers, reviews, and reference works. Much of the text
deals with the structure and func tioning of the molecules bearing
genetic information which reside in the nucleus and with the
processing of this information by the ribosomes resid ing in the
cytoplasm of eukaryotic cells. The mitochondria, which also live in
the cytoplasm of the cells of all eukaryotes, now appear to be
separate little creatures. These, as Lynn Margulis pointed out in
Volume 1, are the colonial posterity of migrant prokaryotes,
probably primitive bacteria that swam into the ancestral precursors
of all eukaryotic cells and remained as symbionts. They have
maintained themselves and their ways ever since, replicating their
own DNA and transcribing an RNA quite different from that of their
hosts. In a similar manner, the chloroplasts in all plants are
self-replicating organelles presumably derived from the blue-green
algae, with their own nucleic acids and ribosomes. Four chapters
are devoted to the nucleic acids and the ribosomal components of
both classes of these semi-independent lodgers. Finally, data from
various sources on genetic variants of enzymes are tabulated for
ready reference, and an evaluation of this information is
attempted."
The United States now spends approximately $115 billion annually to
perform its metal removal tasks using conventional machining
technology. Of this total amount, about $14 billion is invested in
the aerospace and associated industries. It becomes clear that
metal removal technology is a very important candidate for rigorous
investigation looking toward improvement of produc tivity within
the manufacturing system. To aid in this endeavor, work has begun
to establish a new scientific and technical base that will provide
prin ciples upon which manufacturing decisions may be based. One of
the metal removal areas that has the potential for great economic
advantages is high-speed machining and related technology. This
text is con cerned with discussions of ways in which high-speed
machining systems can solve immediate problems of profiling,
pocketing, slotting, sculpturing, facing, turning, drilling, and
thin-walled sectioning. Benefits to many existing programs are
provided by aiding in solving a current management production
problem, that of efficiently removing large volumes of metal by
chip removal. The injection of new high-rate metal removal
techniques into conventional production procedures, which have
remained basically unchanged for a cen tury, presents a formidable
systems problem, both technically and man agerially.The proper
solution requires a sophisticated, difficult process whereby
management-worker relationships are reassessed, age-old machine
deSigns reevaluated, and a new vista of product/process planning
and design admitted."
Despite the dramatic proliferation of research, clinical
perspectives, and first-person accounts of Asperger Syndrome (AS)
in the last 15 years, much of this information has focused on the
application of the diagnosis to children, even though AS displays
persistence over time in individuals. This book is one of the only
guides to Asperger Syndrome as it manifests itself in adults. It
integrates research and clinical experience to provide mental
health professionals with a comprehensive discussion of AS in
adulthood, covering issues of diagnosis as well as co-morbid
psychiatric conditions, psychosocial issues, and various types of
interventions from psychotherapy to psychopharmacology. It also
discusses basic diagnostic criteria, controversies about the
disorder, and possible interventions and treatments for dealing
with the disorder."
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