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Research centering on blood flow in the heart continues to hold an
important position, especially since a better understanding of the
subject may help reduce the incidence of coronary arterial disease
and heart attacks. This book summarizes recent advances in the
field; it is the product of fruitful cooperation among
international scientists who met in Japan in May, 1990 to discuss
the regulation of coronary blood flow.
The principal objective of this symposium was to bring together
investigators from all over the world who work in diverse areas of
research but share a common interest in the physiologic and
pathophysiologic funetions of the nueleoside adenosine. In 1978,
the "International Conference on Physiological and Regulatory
Funetions of Adenosine and Adenine Nueleotides," held in Banff,
Canada, served as an effective catalyst in enabling scientists with
differ ent points of view to exchange information and ideas on this
subject. Since 1978, the amount of research on different as peets
of adenosine metabolism, mechanism of action, transport, and
function in various tissues (in both nor maI and abnormal states)
has increased exponentially, and there was an urgent need for
another meeting for updating information on this burgeoning
subject. The focus of the meeting was extremely sharp, but the
scope of the subject material was very broad. Scientists
categorized as chemists, biochemists, physiologists,
pharmacologists, and immunologists, working with cells and eelI
fragments, with tissues such as heart, brain, musele, fat, kidney,
and with human beings having immune deficiency diseases
participated in the sym posium. They had an opportunity to air
their differences, reinforce their areas of agreement, and, most
important, they educated each other with respeet to research on
adenosine; it is hoped that they also enriched their own research
programs from the information they gained from their fellow
participants."
The principal objective of this symposium was to bring together
investigators from all over the world who work in diverse areas of
research but share a common interest in the physiologic and
pathophysiologic funetions of the nueleoside adenosine. In 1978,
the "International Conference on Physiological and Regulatory
Funetions of Adenosine and Adenine Nueleotides," held in Banff,
Canada, served as an effective catalyst in enabling scientists with
differ ent points of view to exchange information and ideas on this
subject. Since 1978, the amount of research on different as peets
of adenosine metabolism, mechanism of action, transport, and
function in various tissues (in both nor maI and abnormal states)
has increased exponentially, and there was an urgent need for
another meeting for updating information on this burgeoning
subject. The focus of the meeting was extremely sharp, but the
scope of the subject material was very broad. Scientists
categorized as chemists, biochemists, physiologists,
pharmacologists, and immunologists, working with cells and eelI
fragments, with tissues such as heart, brain, musele, fat, kidney,
and with human beings having immune deficiency diseases
participated in the sym posium. They had an opportunity to air
their differences, reinforce their areas of agreement, and, most
important, they educated each other with respeet to research on
adenosine; it is hoped that they also enriched their own research
programs from the information they gained from their fellow
participants."
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