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Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion (Paperback, Softcover reprint of the original... Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion (Paperback, Softcover reprint of the original 1st ed. 1993)
Peter E. Lipsky, Robert Rothlein, Takashi K. Kishimoto, Ronald B. Faanes, C. Wayne Smith
R1,505 Discovery Miles 15 050 Ships in 10 - 15 working days

Leukocyte adhesion molecules have been the subject of intense basic and preclinical research. Results from clinical trials obtained sofar with antibodies directed towards these surface proteins offer promise for the prevention of graft rejection and effective treatment of acute and chronic inflammatory disease. This volume presents a comprehensive review of contemporary research on the structure, function and regulation of leukocyte adhesion molecules and their ligands, from the molecular to the clinical level. The blend of basic science and clinical applications presented in Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion provides clear evidence of the biological importance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion. It will appeal to a broad range of readers in immunology and cell biology.

Leukocyte Adhesion Molecules - Proceedings of the First International Conference on: "Structure, Function and Regulation of... Leukocyte Adhesion Molecules - Proceedings of the First International Conference on: "Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion", Held in Titisee, West Germany, September 28 - October 2, 1988 (Paperback, Softcover reprint of the original 1st ed. 1990)
Timothy A Springer, Donald C. Anderson, Alan S. Rosenthal, Robert Rothlein
R1,472 Discovery Miles 14 720 Ships in 10 - 15 working days

Leukocyte adhesion molecules promise to be highly effective as antigens in the antibody-directed leucocyte elimination treatment prior to grafting or in cases of acute and chronic inflammatory disease. This comprehensive review of contemporary research provides thorough discussions of the structure of these molecules, their "in vitro "function, and the role that they play "in vivo" as evidenced by results shown in inflammatory models where antibodies against these molecules are given to inhibit their function. The blend of basic science and clinical applications provides clear evidence of the biological relevance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion.

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