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Leukocyte adhesion molecules have been the subject of intense basic
and preclinical research. Results from clinical trials obtained
sofar with antibodies directed towards these surface proteins offer
promise for the prevention of graft rejection and effective
treatment of acute and chronic inflammatory disease. This volume
presents a comprehensive review of contemporary research on the
structure, function and regulation of leukocyte adhesion molecules
and their ligands, from the molecular to the clinical level. The
blend of basic science and clinical applications presented in
Structure, Function and Regulation of Molecules Involved in
Leukocyte Adhesion provides clear evidence of the biological
importance of cell-cell interactions and the many potential
clinical dividends afforded by understanding the molecular basis of
cell adhesion. It will appeal to a broad range of readers in
immunology and cell biology.
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Leukocyte Adhesion Molecules - Proceedings of the First International Conference on: "Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion", Held in Titisee, West Germany, September 28 - October 2, 1988 (Paperback, Softcover reprint of the original 1st ed. 1990)
Timothy A Springer, Donald C. Anderson, Alan S. Rosenthal, Robert Rothlein
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R1,560
Discovery Miles 15 600
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Leukocyte adhesion molecules promise to be highly effective as
antigens in the antibody-directed leucocyte elimination treatment
prior to grafting or in cases of acute and chronic inflammatory
disease. This comprehensive review of contemporary research
provides thorough discussions of the structure of these molecules,
their "in vitro "function, and the role that they play "in vivo" as
evidenced by results shown in inflammatory models where antibodies
against these molecules are given to inhibit their function. The
blend of basic science and clinical applications provides clear
evidence of the biological relevance of cell-cell interactions and
the many potential clinical dividends afforded by understanding the
molecular basis of cell adhesion.
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