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Main goal of the work was the development of a complete bronchial
clearance model including a fast clearance phase represented by the
mucociliary escalator as well as a slow clearance phase which
describes long-term clearance mechanisms. The model was applied to
healthy lungs and, after some specific modifications, also to lungs
of COPD-patients. Beside the extensive modeling of bronchial
clearance, major interests were focused on the improvement of the
existing stochastic deposition model by a) the development of
generation-specific correction factors describing enhanced particle
deposition in the proximal airways due to inertial impaction and b)
the computation and visualization of spatial deposition patterns,
better reflecting the complex behaviour of inhaled particles.
Concerning the reliable modeling of bronchial clearance, several
approaches were introduced, ranging from the mathematical
description of single mechanisms over the stochastic formulation of
fast and slow clearance phases to the creation of a
multicompartmental model. Independent of the used approach,
computed clearance data always corresponded well with available
results from various inhalation experiments.
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