Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.

Natural Plant Products in Inflammatory Bowel Diseases: Preventive and Therapeutic Potential organizes all evidence to understand which natural products are the first steps of investigation and which have strong evidence of their effects in inflammatory bowel diseases, have been tested in clinical trials, and have received approval to be officially used. In addition to providing information regarding the research with natural products in inflammatory bowel diseases, this reference will also highlight the molecular mechanisms behind the effects of natural products in inflammatory bowel diseases with the aid of figures, video animations and dynamic tables. Compiled from research group members from different parts of the world and specialized in inflammatory bowel diseases and related topics, this important reference will be useful to health professionals, researchers, professors, and industry managers as it provides helpful information on the subject, with the potential to inspire health care, relevant research and product innovation.

Global Health Informatics: How Information Technology Can Change Our Lives in a Globalized World discusses the critical role of information and communication technologies in health practice, health systems management and research in increasingly interconnected societies. In a global interconnected world the old standalone institutional information systems have proved to be inadequate for patient-centered care provided by multiple providers, for the early detection and response to emerging and re-emerging diseases, and to guide population-oriented public health interventions. The book reviews pertinent aspects and successful current experiences related to standards for health information systems; digital systems as a support for decision making, diagnosis and therapy; professional and client education and training; health systems operation; and intergovernmental collaboration.

When choosing the technology options to develop a wireless sensor network (WSN), it is vital that their performance levels can be assessed for the type of application intended. This book describes the different technology options - MAC protocols, routing protocols, localisation and data fusion techniques - and provides the means to numerically measure their performance, whether by simulation, mathematical models or experimental test beds. Case studies, based on the authors' direct experience of implementing wireless sensor networks, describe the design methodology and the type of measurements used, together with samples of the performance measurements attained.
The book will enable you to answer vital questions such as:
* How long will my network remain alive given the amount of sensing required of it?
* For how long should I set the sleeping state of my motes?
* How many sensors should I distribute to meet the expected requirements of the application?
* What type of throughput should I expect as a function of the number of nodes deployed and the radio interface chosen (whether it be Bluetooth or Zigbee)?
* How is the Packet Error Rate of my Zigbee motes affected by the selection of adjacent frequency sub bands in the ISM 2.4GHz band?
* How is the localisation precision dependant on the number of nodes deployed in a corridor?
Communications and signal processing engineers, researchers and graduate students working in wireless sensor networks will find this book an invaluable practical guide to this important technology.
""This book gives a proper balance between theory and application; it is a book for those R&D engineers that want to appreciate both why, how and in which domains Wireless Sensor Networks can be best applied."" - Fabio Bellifemine, Telecom Italia
""This book is a thorough and accessible exposition on wireless sensor networks with a good balance between theory and practice; it is valuable for both students and practicing engineers, and is an essential addition for engineering libraries."" - Professor Moe Win, Associate Professor at the Laboratory for Information and Decision Systems (LIDS), Massachusetts Institute of Technology
*Only book to examine wireless sensor network technologies and assess their performance capabilities against possible applications
*Enables the engineer to choose the technology that will give the best performance for the intended application
*Case studies, based on the authors' direct experience of implementing wireless sensor networks, describe the design methodology and the type of measurements used, together with samples of the performance measurements attained.

Five more episodes from the first series of the CGI-animated franchise in which the Autobots and Decepticons return to do battle once again. This time around, Bulkhead and Arcee have to investigate a strange energy signal. The episodes are: 'Operation: Breakdown', 'Crisscross', 'Metal Attraction', 'Rock Bottom' and 'Partners'.

This book collects results from ad hoc surveys on firms pricing behavior conducted in 2003 and 2004 by nine National central banks of the Euro area in the context of a joint research project (Eurosystem Inflation Persistence Network). These surveys have proved to be an efficient way to test theories on the pricing strategies of economic agents, documenting, in qualitative terms, the underlying rationale of the observed pricing patterns. The book provides an unprecedented amount of information from more than 11,000 euro area firms, addressing issues such as the relevance of nominal and real rigidities, the information set used by firms in the price setting process, the strategy followed to review prices, the frequency of both price reviews and price changes, the reasons underlying price stickiness, and asymmetries in price adjustment. It also compares results for the euro area to those obtained for other countries by similar studies. Finally, it draws the main implications for theoretical modeling and for monetary policy.

This book is an account of a study which provided unique information on trends in growth and respiratory health in British children over 25 years, with methodological discussion and other major findings including risk factors for impaired growth, obesity, respiratory disease and the distribution of coronary heart disease factors. The book provides information on trends in growth, height weight for height and subcutaneous arm tissue, and in respiratory health, asthma attacks and related symptoms, in children aged 5 to 11 years, from 1972 to 1994. It provides information on risk factors for impaired growth, obesity and respiratory disease, and on the distribution of risk factors for coronary heart disease in children. The contribution of the National Health and Growth Study extended to topics such as the effects of changes in welfare policy, under-diagnosis and under-treatment of asthma, nocturnal enuresis, disturbed sleep, the impact of passive smoking on the health of children, and the relation of lung function to the child's intra-uterine environment and to passive smoking. The methodological issues in relation to the conduct of the study and analysis of the data are discussed in non-technical language. Each contribution of the study is discussed in relation to current literature, which is fully referenced throughout.

A guide to disrupting harmful mindsets and practices in our schools so that students can thrive where they are.In many schools and districts, students of color living in low-income communities are told in simple and covert ways every day that they must leave their communities if they want to be successful. The message may be well-intentioned, but the leave to succeed (L2S) mindset is a dangerous narrative that affects students' sense of self. Students start to wonder: Are low-income or marginalized communities inherently "bad"? What happens to the people who don't "make it out"? Who is worthy of success? Instead, Nancy GutiÉrrez and Roberto Padilla turn the L2S mindset on its head to interrogate how school and district leaders can nurture and support students to find success in their own communities. They share real-world vignettes, reflection questions, and clear and simple tips to build an asset-based, uplifting approach that honors the backgrounds, cultures, and strengths of Black and Brown communities. You will learn how to * Recognize how the L2S mindset is pervasive in many schools. Encourage students to develop their unique stories of self that highlight their cultural backgrounds. Build schools that are innovative, offer a community-rich curriculum, and are held accountable to provide deep learning to all students. Rewrite the dominant narrative in your school system to become a disruptive yet positive force in education. Embrace the moral responsibility to be an equitable, fair, and compassionate leader to all students, no matter their socioeconomic backgrounds. No one is truly served by deficit-based narratives, and for every student to feel valued and affirmed, schools and districts must embrace the idea that any student in any school can stay in their community and prevail.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

What link might connect two far worlds like quantum theory and music? There is something universal in the mathematical formalism of quantum theory that goes beyond the limits of its traditional physical applications. We are now beginning to understand how some mysterious quantum concepts, like superposition and entanglement, can be used as a semantic resource.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

This book provides the first comprehensive appraisal of the paradigm shift towards mandatory sustainability requirements in EU public procurement law. Traditionally, EU public procurement law focused on ‘how to buy’, dictating procedural rules so that public buyers in the Member States did not discriminate against suppliers and service providers from other Member States. Mandatory green and social requirements mean that, with a view to achieving sustainable development goals and mitigating climate change, the EU will limit this discretionary power for public buyers, pushing them to acquire more sustainable goods and services. Based on legal analysis informed by economic perspectives, the book aims to contribute to an understanding and critical discussion of the EU legislator’s move towards regulating ‘what to buy’. The book discusses the role of the Public Procurement Directives in relation to this paradigm shift, as well as various other sectoral legislative instruments that have been revamped or newly introduced in light of the European Green Deal. The paradigm shift is analysed from different perspectives, including subsidiarity, alternative regulation, economics and public purchasing. The book includes novel sectoral studies on transport, food, clothing, and construction, discussing how change is taking place and what its major challenges are for the future. Chapters on Italy, the Netherlands, Spain, and more, offer case studies of Member States that have already introduced mandatory requirements and highlight lessons learnt. This is an essential book for professionals working with public procurement law in academia and practice, and to those engaged in achieving public policy objectives in light of climate change and social injustice.

Functionalized Nanomaterials for Biosensing and Bioelectronics Applications: Trends and Challenges describes current and future opportunities for integrating the unique properties of two-dimensional nanomaterials with bioelectronic interfaces. Sections focus on background information and fundamental concepts, review the available functionalized nanomaterials and their properties, explore the integration of functionalized nanomaterials with bioelectronics, including available fabrication and characterization methods, electrical behavior at the interface, and design and synthesis guidelines, and review examples of microsystems where functionalized nanomaterials are being integrated with bioelectronics. This book is suitable for researchers and practitioners in academia and R&D working in materials science and engineering, analytical chemistry and related fields.

Bionanocatalysis: From Design to Applications discusses recent advances in nano-biocatalysis, fundamental design concepts and their applications in a variety of industry sectors. Strategies for immobilizing enzymes onto nanocarriers, made from polymers, silicas, carbons, and metals, by physical adsorption, covalent binding, cross-linking, or specific ligand spacers are also discussed as are the advantages, problems and solutions derived from the use of non-porous nanomaterials for enzyme immobilization. This is an important reference source for materials scientists and chemical engineers who would like to learn more about how nanobiocatalysts are designed and used. Biocatalysis has emerged as a sustainable technique to synthesize valuable commodity chemicals with wide applications in various industrial domains, such as in agriculture, cosmetics, pharmaceuticals, biofuels, biosensors, biofuel cells, biochemicals, and foods. The synergistic integration of bio-catalysis engineering with nanostructured materials, as unique multifunctional carrier matrices, has emerged as a new interface of nano-biocatalysis (NBC).

Lyrical, magical, tender and true - Michael Morpurgo Madurer is the son of a great lord, with untold wealth, but he is also the victim of a mysterious disease that means he cannot be exposed to sunlight or fresh air. He is confined to three windowless rooms inside a palace, but his doting father summons a famous artist to cover the walls of the rooms with paintings showing the world his son cannot experience for real. As the painter works on his murals, his relationship with the boy begins to deepen until they forge a firm friendship. How can he show this child the beauty of the world with only his paintbrush to work with? Glowrushes is a heartbreakingly beautiful classic of Italian children's literature, published here in English for the first time.