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One of the hallmarks of aging is the decreased capacity to adapt to
changes in the environment. In a constant, controlled environment,
it is often difficult to distin guish the functioning of the young
organism from that of the old. However, when stresses are
applied-temperature stresses, dietary stresses, infection,
emotional stresses-the differences are more apparent. Frequently,
the response ofthe old is delayed and may never reach the same
mag'nitude as the young. These responses, in most cases, are
mediated by the neuroendocrine system, which communicates via
hormones, neurotransmitters, and related substances. Thus, it is
important to understand the age-related changes that take place in
the secretion and act ion of these substances and how these changes
relate to the well-being of the whole organism. Indeed, the
"neuroendocrine theory of aging" proposes that almost all of the
characteristics of aging can be accounted for by dysfunction of the
neuroendocrine system. A book on endocrine function and aging is
particularly relevant at this time. With the advent of the
techniques of molecular biology, there has bee an explo sion of
knowledge concerning hormone secretion and action. Hormones, pro
hormones, hormone receptors, and "second messenger" mediators
rapidly are being cloned and sequenced. Such knowledge gives us
important insights into the molecular workings of these substances
as well as into the genetic hasis of endo crine dysfunction. These
new tools are now being applied to the problem of age related
changes in endocrine function."
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