This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology.

"Hauser and Wagner have presented the new possibilities of Mammalian Cell Biology in a very informative and stimulating manner." Prof. Dr. Hans Fritz, Ludwig-Maximilians-University Munich

This, the 38th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains extended and revised versions of six papers selected from the 68 contributions presented at the 27th International Conference on Database and Expert Systems Applications, DEXA 2016, held in Porto, Portugal, in September 2016. Topics covered include query personalization in databases, data anonymization, similarity search, computational methods for entity resolution, array-based computations in big data analysis, and pattern mining.

This volume constitutes the refereed proceedings of the three workshops held at the 29th International Conference on Database and Expert Systems Applications, DEXA 2018, held in Regensburg, Germany, in September 2018: the Third International Workshop on Big Data Management in Cloud Systems, BDMICS 2018, the 9th International Workshop on Biological Knowledge Discovery from Data, BIOKDD, and the 15th International Workshop on Technologies for Information Retrieval, TIR. The 25 revised full papers were carefully reviewed and selected from 33 submissions. The papers discuss a range of topics including: parallel data management systems, consistency and privacy cloud computing and graph queries, web and domain corpora, NLP applications, social media and personalization

This volume, the 36th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains eight revised, extended papers selected from the 3rd International Conference on Future Data and Security Engineering, FDSE 2016, and the 10th International Conference on Advanced Computing and Applications, ACOMP 2016, which were held in Can Tho City, Vietnam, in November 2016. Topics covered include big data analytics, massive dataset mining, security and privacy, cryptography, access control, deep learning, crowd sourcing, database watermarking, and query processing and optimization.

This volume, the 35th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains five fully-revised selected regular papers focusing on data quality, social-data artifacts, data privacy, predictive models, and e-health. Specifically, the five papers present and discuss a data-quality framework for the Estonian public sector; a data-driven approach to bridging the gap between the business and social worlds; privacy-preserving querying on privately encrypted data in the cloud; algorithms for the prediction of norovirus concentration in drinking water; and cloud computing in healthcare organizations in Saudi Arabia.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the 33rd issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains five revised selected regular papers. Topics covered include distributed massive data streams, storage systems, scientific workflow scheduling, cost optimization of data flows, and fusion strategies.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This volume, the 32nd issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, focuses on Big Data Analytics and Knowledge Discovery, and contains extended and revised versions of five papers selected from the 17th International Conference on Big Data Analytics and Knowledge Discovery, DaWaK 2015, held in Valencia, Spain, during September 1-4, 2015. The five papers focus on the exact detection of information leakage, the binary shapelet transform for multiclass time series classification, a discrimination-aware association rule classifier for decision support (DAAR), new word detection and tagging on Chinese Twitter, and on-demand snapshot maintenance in data warehouses using incremental ETL pipelines, respectively. discovery,="" contains="" extended="" revised="" versions="" five="" papers="" selected="" from="" 17th="" international="" conference="" discovery="" (dawak="" 2015),="" held="" in="" valencia,="" spain,="" during="" september="" 1-4,="" 2015.="" focus="" exact="" detection="" information="" leakage,="" binary="" shapelet="" transform="" for="" multiclass="" time="" series="" classification,="" a="" discrimination-aware="" association="" rule="" classifier="" decision="" support="" (daar),="" new="" word="" tagging="" chinese="" twitter,="" on-demand="" snapshot="" maintenance="" warehouses="" using="" incremental="" etl="" pipelines,="" respectively.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the 29th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains four revised selected regular papers. Topics covered include optimization and cluster validation processes for entity matching, business intelligence systems, and data profiling in the Semantic Web.

This, the 28th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains extended and revised versions of six papers presented at the 26th International Conference on Database- and Expert-Systems Applications, DEXA 2015, held in Valencia, Spain, in September 2015. Topics covered include efficient graph processing, machine learning on big data, multistore big data integration, ontology matching, and the optimization of histograms for the Semantic Web.

This, the 27th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains extended and revised versions of 12 papers presented at the Big Data and Technology for Complex Urban Systems symposium, held in Kauai, HI, USA in January 2016. The papers explore the use of big data in complex urban systems in the areas of politics, society, commerce, tax, and emergency management.

This volume, the 23rd issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems,focuses on information and security engineering. It contains five revised and extended papers selected from the proceedings of the First International Conference on Future Data and Security Engineering, FDSE 2014, held in Ho Chi Minh City, Vietnam, November 19-21, 2014. The titles of the five papers are as follows: A Natural Language Processing Tool for White Collar Crime Investigation; Data Leakage Analysis of the Hibernate Query Language on a Propositional Formulae Domain; An Adaptive Similarity Search in Massive Datasets; Semantic Attack on anonymized Transactions; and Private Indexes for Mixed Encrypted Databases.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments.This volume, the 26th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, focuses on Data Warehousing and Knowledge Discovery from Big Data, and contains extended and revised versions of four papers selected as the best papers from the 16th International Conference on Data Warehousing and Knowledge Discovery (DaWaK 2014), held in Munich, Germany, during September 1-5, 2014. The papers focus on data cube computation, the construction and analysis of a data warehouse in the context of cancer epidemiology, pattern mining algorithms, and frequent item-set border approximation.

This, the 25th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains five fully revised selected papers focusing on data and knowledge management systems. Topics covered include a framework consisting of two heuristics with slightly different characteristics to compute the action rating of data stores, a theoretical and experimental study of filter-based equijoins in a MapReduce environment, a constraint programming approach based on constraint reasoning to study the view selection and data placement problem given a limited amount of resources, a formalization and an approximate algorithm to tackle the problem of source selection and query decomposition in federations of SPARQL endpoints, and a matcher factory enabling the generation of a dedicated schema matcher for a given schema matching scenario.

This, the 24th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains extended and revised versions of seven papers presented at the 25th International Conference on Database and Expert Systems Applications, DEXA 2014, held in Munich, Germany, in September 2014. Following the conference, and two further rounds of reviewing and selection, six extended papers and one invited keynote paper were chosen for inclusion in this special issue. Topics covered include systems modeling, similarity search, bioinformatics, data pricing, k-nearest neighbor querying, database replication, and data anonymization.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the 18th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains extended and revised versions of seven papers presented at the 24th International Conference on Database and Expert Systems Applications, DEXA 2013, held in Prague, in the Czech Republic, in August 2013. Following the conference, and two further rounds of reviewing and selection, five extended papers and two invited keynote papers were chosen for inclusion in this special issue. The subject areas covered include argumentation, e-government, business processes, predictive traffic estimation, semantic model integration, top-k query processing, uncertainty handling, graph comparison, community detection, genetic programming, and web services.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the 17th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains extended and revised versions of five papers, selected from the 24 full and 8 short papers presented at the 15th International Conference on Data Warehousing and Knowledge Discovery, DaWaK 2013, held in Prague, The Czech Republic, in August 2013. Of the five papers, two cover data warehousing aspects related to query processing optimization in advanced platforms, specifically Map Reduce and parallel databases, and three cover knowledge discovery, specifically the causal network inference problem, dimensionality reduction, and the quality-of-pattern-mining task.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the 16th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains extended and revised versions of 7 papers, selected from the 30 papers presented at the International Conference on Advanced Computing and Applications, ACOMP 2013, held October 23-25, 2013, in Ho Chi Minh City, Vietnam. Topics covered include data engineering, information retrieval, query processing and optimization, energy-efficient resource allocation, and security and privacy.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This special issue contains extended and revised versions of 4 papers, selected from the 25 papers presented at the satellite events associated with the 17th East-European Conference on Advances in Databases and Information Systems (ADBIS 2013), held on September 1-4, 2013 in Genoa, Italy. The three satellite events were GID 2013, the Second International Workshop on GPUs in Databases; SoBI 2013, the First International Workshop on Social Business Intelligence: Integrating Social Content in Decision Making; and OAIS 2013, the Second International Workshop on Ontologies Meet Advanced Information Systems. The papers cover various topics in large-scale data and knowledge-centered systems, including GPU-accelerated database systems and GPU-based compression for large time series databases, design of parallel data warehouses, and schema matching. The special issue content, which combines both theoretical and application-based contributions, gives a useful overview of some of the current trends in large-scale data and knowledge management and will stimulate new ideas for further research and development within both the scientific and industrial communities.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the 14th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains four revised selected regular papers. Topics covered include data stream systems, top-k query processing, semantic web service (SWS) discovery, and XML functional dependencies.

This book constitutes the refereed proceedings of the First International Conference on Future Data and Security Engineering, FDSE 2014, held in Ho Chi Minh City, Vietnam, in November 2014. The 23 full papers presented were carefully reviewed and selected from 66 submissions. They have been organized in the following topical sections: big data analytics and applications; security and privacy engineering; crowdsourcing and social network data analytics; biometrics and data protection in smart devices; cloud data management and applications; and advances in query processing and optimization.

This, the 13th issue of Transactions on Large-Scale Data and Knowledge-Centered Systems, contains six revised selected regular papers. Topics covered include federated data sources, information filtering, web data clouding, query reformulation, package skyline queries and SPARQL query processing over a LaV (Local-as-View) integration system.

This, the 11th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains five selected papers focusing on Advanced Data Stream Management and Processing of Continuous Queries. The contributions cover different methods for avoiding unauthorized access to streaming data, modeling complex real-time behavior of stream processing applications, comparing different event-centric and data-centric platforms for the development of applications in pervasive environments, capturing localized repeated associative relationships from multiple time series, and obtaining uniform and fresh sampling strategies over input data streams generated by large open systems containing malicious participants.

This, the 12th issue of Transactions on Large-Scale Data and Knowledge-Centered Systems, contains five revised selected regular papers. Topics covered include schema matching and schema mapping, update propagation in decision support systems, routing methods in peer-to-peer systems, distributed stream analytics and dynamic data partitioning.

The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data-and knowledge-centered systems in large-scale environments. This, the 10th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains seven full papers chosen following two additional rounds of reviewing from revised and extended versions of a selection of papers presented at DEXA 2012. Topics covered include formal modelling and verification of web services, incremental computation of skyline queries, the implication problem for XML keys, lossless data compression, declarative view selection methods, time awareness in recommender systems, and network data mining."