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The growth and function of many tissues are influenced by hormones.
Therefore it is quite understandable that hormones play a role in
the development and treatment of malignant tumors. Numerous
publications address this topic; however, the results of many
studies are controversial and have not been unequivocally accepted.
For nearly 50 years the carcinogenic effect of steroid hormones has
been under debate, and their therapeutic value a matter of
discussion for equally as long. The present volume concentrates on
substantiated data first obtained from the study of tumors
developing from hormone regulated or hormone-producing tissue,
e.g., the thyroid, adrenal glands, prostate, and the female genital
tract. Through a joint approach from the field of molecular
biology, biochemistry, and histopathology, advances in the
management of these tumors have been elaborated. Another exciting
example is the endo nuclear diagnosis of adrenal tumors.
Antihormones, i.e. antian drogens or GnRH analogues have proved to
be important indeed since they exhibit a destructive effect on
prostate carcinomas and breast cancer. Further improvements can be
expected in the localization of hormones in tumor tissue by
specific antibodies. A special chapter is dedicated to the diffuse
endocrine cell system (DECS), the clinical significance of which
has mainly become obvious in the gastroenteropancreatic tract.
Malignancies originating from the urogenital tract account for
about 20% of all solid neoplasias. The various tumor types,
including carcinoma of the prostate, transitional cell carcinoma,
renal cell carcinoma, and testicular germ cell tumors, differ
widely in terms of biological features, in cidence and appearance,
diagnostic work-up and manage ment. It is not surprising that this
complexity of urologic oncology with its related problems has
increasingly attracted both experimental investigators and clinical
experts. Only time will tell whether the achievements that today
are con sidered* as progress will turn out to be significant
contribu tions towards the ultimate goal: the cure of the patients'
life-threatening diseases with little or no side effects. How ever,
many innovations and improvements have already taken place in the
field of urologic oncology within recent years. The high pace of
innovative development requires continuous, thorough, and critical
updating of our kowledge so that persisting deficits can be
defined: the basic require ment for posing new scientific
questions. The following examples may serve to illustrate the
recent developments and the resulting new problems and questions:
Recently, it has become evident that carcinoma of the prostate must
be detected earlier to enable us to cure more of the affected
patients in the future than currently.
Dieser Band enthalt die Vortrage anlasslich der 38. Tagung der
Deutschen Gesellschaft fur Urologie in Wurzburg. Die Hauptthemen
behandeln die Lymphknotenchirugie bei urologischen Tumoren und das
Prostatakarzinom sowie Fragen der Nierentransplantation."
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