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Extensively revised, comprehensive content from leading global
contributors ensures that Hematology, 8th Edition, remains your #1
choice for expert guidance in all areas of this rapidly advancing
subspecialty. This edition reflects the numerous advances that are
redefining the field and dramatically influencing new approaches to
diagnosis, treatment, and outcomes. Well-illustrated and clinically
focused, it details the basic science and clinical practice of
hematology and hematopoietic cellular therapy-covering virtually
all aspects of hematology in one definitive resource. Covers all
hematologic disorders, including comprehensive discussions of
hematologic malignancies, individualized patient care, cell-based
therapies, transplantation, transfusion medicine, hemostasis,
thrombosis, and consultative hematology-in one convenient
volume. Provides state-of-the-art guidance from global
experts at the forefront of the latest research and clinical
practice. Provides extensive updates throughout on basic
science research, advances in molecular diagnostics, new drugs,
immunotherapies, personalized medicine, laboratory medicine,
transfusion medicine, stem cell transplantation, and clinical
treatment for all hematologic malignancies and
non-malignancies Contains new chapters on gene editing; the
impact of mitochondria on hematopoiesis; myelodysplastic
syndrome/myeloproliferative neoplasm overlap syndromes;
immunotherapy and management of its toxicities; transfusion
medicine in sickle cell disease; principles of radiation therapy;
and COVID-19, including complications of vaccination and its impact
on the hematologic system. Discusses many new advances in
the field, including details and the future of gene therapy for
hemophilia, gene editing for sickle cell disease and thalassemia,
the evolution of cellular therapy, use of cells, transfusion
medicine vs. protein therapy, gene sequencing, immunotherapy, and
new targeted drugs. Includes more decision-making algorithms
for formulating diagnoses and personalized treatment plans for
those highly complex disorders that require individualized
approaches. Addresses the effects of aging on hematopoiesis
and on the manifestations of a variety of hematologic
disorders. Discusses cardio-oncology and its impact on the
treatment of patients with hematologic disorders. Presents
relevant basic science as background for clinical application in
later sections. An eBook version is included with purchase.
The eBook allows you to access all of the text, figures and
references, with the ability to search, customize your content,
make notes and highlights, and have content read aloud.Â
This issue of Hematology/Oncology Clinics, guest edited by Drs.
Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal,
is dedicated to Myeloproliferative Neoplasms. This issue is one of
six selected each year by the series consulting editors, Drs.
George P. Canellos and Edward J. Benz. Topics in this issue
include-but are not limited to- Overview of pathophysiology and
potential drug targets, The role of the megakaryocyte, Epigenetics,
Genetics, Novel technologies for understanding MPN biology,
Important pathology considerations, Current Clinical
investigations, Quality of life, Application of stem cell therapy,
Immunotherapy approaches, Clinical unmet needs in ET/PV,
Accelerated and blast phase MPNs, Epidemiology, Thrombotic and
hemorrhagic complications, Murine modeling, The microenvironment in
MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical
trial designs.
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Dear Papa, Dear Charley: Volume II - The Peregrinations of a Revolutionary Aristocrat, as Told by Charles Carroll of Carrollton and His Father, Charles Carroll of Annapolis, with Sundry Observations on Bastardy, Child-Rearing, Romance, Matrimony, Commerce, Tobacco, Slavery, and the Politics of Revolutionary America (Paperback, Volume 2)
Ronald Hoffman, Sally D. Mason, Eleanor S. Darcy
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R1,429
Discovery Miles 14 290
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Ships in 10 - 15 working days
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This compelling collection of correspondence between a father and a
son documents the history of eighteenth-century America through the
intimate story of a family and the journey from boyhood to
political prominence of its most illustrious member, Charles
Carroll of Carrollton, the only Roman Catholic signer of the
Declaration of Independence. Beginning in the late 1740s, when
""Papa"" (Charles Carroll of Annapolis) sent ""Charley"" (Charles
Carroll of Carrollton) away from his native Maryland to be educated
in Europe, the letters present a new perspective on colonial and
Revolutionary America as the lived experience of Roman Catholics,
whose defiant adherence to their faith denied them the civil rights
and guarantees - including the right to hold office and to vote -
that their Protestant counterparts enjoyed. This context
accentuates the drama of Charley's rise to power during the
Revolution, the necessity of the political and economic compromises
he felt compelled to make, and the ultimately tragic personal price
exacted by his success. Bringing the Carroll's public and private
lives sharply into focus, these volumes present the past in its
fullest human dimensions.
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Dear Papa, Dear Charley: Volume I - The Peregrinations of a Revolutionary Aristocrat, as Told by Charles Carroll of Carrollton and His Father, Charles Carroll of Annapolis, with Sundry Observations on Bastardy, Child-Rearing, Romance, Matrimony, Commerce, Tobacco, Slavery, and the Politics of Revolutionary America (Paperback, Volume 1)
Ronald Hoffman, Sally D. Mason, Eleanor S. Darcy
|
R1,429
Discovery Miles 14 290
|
Ships in 10 - 15 working days
|
This compelling collection of correspondence between a father and a
son documents the history of eighteenth-century America through the
intimate story of a family and the journey from boyhood to
political prominence of its most illustrious member, Charles
Carroll of Carrollton, the only Roman Catholic signer of the
Declaration of Independence. Beginning in the late 1740s, when
""Papa"" (Charles Carroll of Annapolis) sent ""Charley"" (Charles
Carroll of Carrollton) away from his native Maryland to be educated
in Europe, the letters present a new perspective on colonial and
Revolutionary America as the lived experience of Roman Catholics,
whose defiant adherence to their faith denied them the civil rights
and guarantees - including the right to hold office and to vote -
that their Protestant counterparts enjoyed. This context
accentuates the drama of Charley's rise to power during the
Revolution, the necessity of the political and economic compromises
he felt compelled to make, and the ultimately tragic personal price
exacted by his success. Bringing the Carroll's public and private
lives sharply into focus, these volumes present the past in its
fullest human dimensions.
|
Dear Papa, Dear Charley: Volume III - The Peregrinations of a Revolutionary Aristocrat, as Told by Charles Carroll of Carrollton and His Father, Charles Carroll of Annapolis, with Sundry Observations on Bastardy, Child-Rearing, Romance, Matrimony, Commerce, Tobacco, Slavery, and the Politics of Revolutionary America (Paperback, Volume 3)
Ronald Hoffman, Sally D. Mason, Eleanor S. Darcy
|
R1,429
Discovery Miles 14 290
|
Ships in 10 - 15 working days
|
This compelling collection of correspondence between a father and a
son documents the history of eighteenth-century America through the
intimate story of a family and the journey from boyhood to
political prominence of its most illustrious member, Charles
Carroll of Carrollton, the only Roman Catholic signer of the
Declaration of Independence. Beginning in the late 1740s, when
""Papa"" (Charles Carroll of Annapolis) sent ""Charley"" (Charles
Carroll of Carrollton) away from his native Maryland to be educated
in Europe, the letters present a new perspective on colonial and
Revolutionary America as the lived experience of Roman Catholics,
whose defiant adherence to their faith denied them the civil rights
and guarantees - including the right to hold office and to vote -
that their Protestant counterparts enjoyed. This context
accentuates the drama of Charley's rise to power during the
Revolution, the necessity of the political and economic compromises
he felt compelled to make, and the ultimately tragic personal price
exacted by his success. Bringing the Carroll's public and private
lives sharply into focus, these volumes present the past in its
fullest human dimensions.
This title offers relief for a condition affecting seven million
people.
An intergenerational chronicle of the struggles and triumphs of the
Carrolls, a prominent Irish Catholic family in Protestant Maryland.
Charles Carroll (1737-1832) who represents the last of the three
generations of patriarchs, is perhaps best known as the sole Roman
Catholic to sign the Declaration of Independence. Tracing the
Carroll's history from Ireland to Maryland, this account offers a
transatlantic perspective of Anglo-American colonialism and reveals
the often overlooked discrimination that Roman Catholics faced in
colonial America.
At the 1795 treaty council that sealed Anthony Wayne's victory at
Fallen Timbers in northwest Ohio, the Wyandot leader Tarhe spoke
for the assembled Native leaders when he admonished the American
emissaries: "Take care of your little ones; an impartial father
equally regards all his children." Spoken two decades after the
minutemen's shots had echoed across Lexington Green, Tarhe's words
compel historians to reconsider the rosy truisms that customarily
encircle the age of the Early Republic. The essays in this volume
begin to perform this important reexamination of the Native
American experience in the post-Revolutionary period. Tarhe's
eloquent words and similar evidence quoted by the volume's
contributors show that American Indians were not defeated refugees
who dutifully stood aside in the wake of the British defeat, nor
were they passive victims of American expansion. The book's three
parts reflect the dynamic nature of the Native Americans' struggle:
the first provides broad discussions of the interaction between
Native Americans and the United States in the postwar era; the
second traces histories of specific tribal communities; and the
third explores the powerful repertoire of stories and pictures that
Americans used to describe Native Americans to themselves during an
era of national expansion. These essays open up for consideration a
more complex history of the Early Republic. Contributors Colin G.
Calloway, Dartmouth College * R. David Edmunds, University of Texas
at Dallas * Vivien Green Fryd, Vanderbilt University * Reginald
Horsman, University of Wisconsin-Milwaukee * Elise Marienstras,
University of Paris * Joel W. Martin, Franklin and Marshall College
* James H. Merrell, Vassar College * Theda Perdue, University of
North Carolina * Daniel K. Richter, Dickinson College * Daniel H.
Usner Jr., Cornell University * Richard White, Stanford University
This title deals with treating "hyper" children without drugs.
The essays in this volume explore some of the potentially divisive
realities that characterized the Federalist Era. Nine distinguished
authors address themes that include the ideological assumptions
that fueled the political debate, the interrelated character of
social and political history, the role of the courts as an emerging
force in arbitrating and containing conflict, and the expansionist
impulses that pushed the new nation's borders westward. Gordon S.
Wood introduces the collection with an incisive overview of the
bold ambitions and unfulfilled aspirations of the critical first
decade of the United States.
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