Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy-covering virtually all aspects of hematology in one definitive resource. Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology-in one convenient volume.  Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice.  Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies  Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system.  Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs.  Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches.  Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders.  Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders.  Presents relevant basic science as background for clinical application in later sections.  An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. 

This issue of Hematology/Oncology Clinics, guest edited by Drs. Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal, is dedicated to Myeloproliferative Neoplasms. This issue is one of six selected each year by the series consulting editors, Drs. George P. Canellos and Edward J. Benz. Topics in this issue include-but are not limited to- Overview of pathophysiology and potential drug targets, The role of the megakaryocyte, Epigenetics, Genetics, Novel technologies for understanding MPN biology, Important pathology considerations, Current Clinical investigations, Quality of life, Application of stem cell therapy, Immunotherapy approaches, Clinical unmet needs in ET/PV, Accelerated and blast phase MPNs, Epidemiology, Thrombotic and hemorrhagic complications, Murine modeling, The microenvironment in MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical trial designs.

This compelling collection of correspondence between a father and a son documents the history of eighteenth-century America through the intimate story of a family and the journey from boyhood to political prominence of its most illustrious member, Charles Carroll of Carrollton, the only Roman Catholic signer of the Declaration of Independence. Beginning in the late 1740s, when ""Papa"" (Charles Carroll of Annapolis) sent ""Charley"" (Charles Carroll of Carrollton) away from his native Maryland to be educated in Europe, the letters present a new perspective on colonial and Revolutionary America as the lived experience of Roman Catholics, whose defiant adherence to their faith denied them the civil rights and guarantees - including the right to hold office and to vote - that their Protestant counterparts enjoyed. This context accentuates the drama of Charley's rise to power during the Revolution, the necessity of the political and economic compromises he felt compelled to make, and the ultimately tragic personal price exacted by his success. Bringing the Carroll's public and private lives sharply into focus, these volumes present the past in its fullest human dimensions.

This compelling collection of correspondence between a father and a son documents the history of eighteenth-century America through the intimate story of a family and the journey from boyhood to political prominence of its most illustrious member, Charles Carroll of Carrollton, the only Roman Catholic signer of the Declaration of Independence. Beginning in the late 1740s, when ""Papa"" (Charles Carroll of Annapolis) sent ""Charley"" (Charles Carroll of Carrollton) away from his native Maryland to be educated in Europe, the letters present a new perspective on colonial and Revolutionary America as the lived experience of Roman Catholics, whose defiant adherence to their faith denied them the civil rights and guarantees - including the right to hold office and to vote - that their Protestant counterparts enjoyed. This context accentuates the drama of Charley's rise to power during the Revolution, the necessity of the political and economic compromises he felt compelled to make, and the ultimately tragic personal price exacted by his success. Bringing the Carroll's public and private lives sharply into focus, these volumes present the past in its fullest human dimensions.

This compelling collection of correspondence between a father and a son documents the history of eighteenth-century America through the intimate story of a family and the journey from boyhood to political prominence of its most illustrious member, Charles Carroll of Carrollton, the only Roman Catholic signer of the Declaration of Independence. Beginning in the late 1740s, when ""Papa"" (Charles Carroll of Annapolis) sent ""Charley"" (Charles Carroll of Carrollton) away from his native Maryland to be educated in Europe, the letters present a new perspective on colonial and Revolutionary America as the lived experience of Roman Catholics, whose defiant adherence to their faith denied them the civil rights and guarantees - including the right to hold office and to vote - that their Protestant counterparts enjoyed. This context accentuates the drama of Charley's rise to power during the Revolution, the necessity of the political and economic compromises he felt compelled to make, and the ultimately tragic personal price exacted by his success. Bringing the Carroll's public and private lives sharply into focus, these volumes present the past in its fullest human dimensions.

This title offers relief for a condition affecting seven million people.

An intergenerational chronicle of the struggles and triumphs of the Carrolls, a prominent Irish Catholic family in Protestant Maryland. Charles Carroll (1737-1832) who represents the last of the three generations of patriarchs, is perhaps best known as the sole Roman Catholic to sign the Declaration of Independence. Tracing the Carroll's history from Ireland to Maryland, this account offers a transatlantic perspective of Anglo-American colonialism and reveals the often overlooked discrimination that Roman Catholics faced in colonial America.

At the 1795 treaty council that sealed Anthony Wayne's victory at Fallen Timbers in northwest Ohio, the Wyandot leader Tarhe spoke for the assembled Native leaders when he admonished the American emissaries: "Take care of your little ones; an impartial father equally regards all his children." Spoken two decades after the minutemen's shots had echoed across Lexington Green, Tarhe's words compel historians to reconsider the rosy truisms that customarily encircle the age of the Early Republic. The essays in this volume begin to perform this important reexamination of the Native American experience in the post-Revolutionary period. Tarhe's eloquent words and similar evidence quoted by the volume's contributors show that American Indians were not defeated refugees who dutifully stood aside in the wake of the British defeat, nor were they passive victims of American expansion. The book's three parts reflect the dynamic nature of the Native Americans' struggle: the first provides broad discussions of the interaction between Native Americans and the United States in the postwar era; the second traces histories of specific tribal communities; and the third explores the powerful repertoire of stories and pictures that Americans used to describe Native Americans to themselves during an era of national expansion. These essays open up for consideration a more complex history of the Early Republic. Contributors Colin G. Calloway, Dartmouth College * R. David Edmunds, University of Texas at Dallas * Vivien Green Fryd, Vanderbilt University * Reginald Horsman, University of Wisconsin-Milwaukee * Elise Marienstras, University of Paris * Joel W. Martin, Franklin and Marshall College * James H. Merrell, Vassar College * Theda Perdue, University of North Carolina * Daniel K. Richter, Dickinson College * Daniel H. Usner Jr., Cornell University * Richard White, Stanford University

This title deals with treating "hyper" children without drugs.

The essays in this volume explore some of the potentially divisive realities that characterized the Federalist Era. Nine distinguished authors address themes that include the ideological assumptions that fueled the political debate, the interrelated character of social and political history, the role of the courts as an emerging force in arbitrating and containing conflict, and the expansionist impulses that pushed the new nation's borders westward. Gordon S. Wood introduces the collection with an incisive overview of the bold ambitions and unfulfilled aspirations of the critical first decade of the United States.