Enlargement of the EU increases economic diversity and inequality between countries and regions, making cohesion difficult. This book attempts to provide a deeper understanding of the interaction between investment, knowledge spillovers and entrepreneurship; a crucial factor in reducing the economic disparity caused by the geographic expansion of the EU. The book offers new empirical evidence regarding the spatial dimension of investment, entrepreneurship and knowledge spillovers, and features both individual and cross-country analyses. FDI in accession countries is examined, as is the effect of EU integration on own-country investment. Innovative methodologies and unique new models are then used to provide lessons and policy implications for economic growth prospects in the recently enlarged EU. Researchers and policy makers working in the fields of entrepreneurship, innovation, economic growth, economic integration and regional development will find this book to be of great interest. It will also be warmly welcomed by students and academics with an interest in European studies, international economics and regional and urban economics.