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Molecular Hematopathology: An Integrated Case-Based Approach,
provides readers an integrated case-informed learning experience of
Molecular Hematopathology focused on best-practice neoplastic
hematopoietic disorders and related conditions. Through reviews of
diagnostic approaches in which a combination of morphologic
analysis, flow cytometry, and genetic testing (cytogenetics, FISH,
PCR, and/or NGS) are used to best advantage, readers should
significantly expand their understanding. The text is not simply a
catalog of every hematologic neoplasm having a defined cytogenetic
or molecular abnormality, but rather a study of cases whose
evaluations illustrate how specific chromosomal and molecular
findings are used for diagnosis, prognosis, and for consideration
for targeted therapy. Most of the individual chapters include
summary tables that compare the described malignancy with similar
entities, so that a very broad set of specific hematologic is
considered throughout the text. Two sets of quiz questions are also
provided for aiding in self-study. The Appendices include a concise
overview of cytogenetic and molecular techniques, including a
complete guide to reading next generation sequencing (NGS) data.
Standard nomenclature (2017 WHO Classification compliant) is used
throughout. Hematopathology has undergone several revolutionary
periods, including the development of a classification system
defining distinct, "real" entities (later evolved to the current
WHO classification of hematologic neoplasms), advances in
sophisticated immunophenotyping such as flow cytometry, and most
recently, an explosion in molecular/genetic testing that greatly
expands how we understand the pathophysiology of hematologic
disease. The extent, applications, and ramifications of the genomic
revolution are still being developed and explored. This book
demonstrates how novel advances in molecular and cellular biology
translate to modern pathology practice.
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