The role of nutrition in neoplasia has been of longstanding concern. The subject was addressed by investigators in the first decade of this century, but was dropped. Vigorous attention was paid to this area of oncology in the 1940s, primarily due to the efforts of Dr. A. Tannenbaum at the Michael Reese Hospital in Chicago and the group at the University of Wisconsin in Madison. However, interest waned again until the 1970s when the question of diet and cancer was addressed and it has since been at the forefront of cancer research. The present volume (7) of Human Nutrition: A Comprehensive Treatise summarizes current knowledge in the area of nutrition and cancer. The first chapter is an overview written by John Higginson, whose contribution to understanding of cancer and nutrition spans several decades. The next essays cover epidemiology and physiology. The ensuing chapters address, in tum, those dietary factors relating to nutrition and cancer, namely, carbohydrates, protein, fat, cholesterol, calories, lipotropics, fiber, fruits and vegetables, vitamins, and alcohol. In a field moving as rapidly as this one is now, we can expect to miss a few late-breaking developments, but generally, the literature has been well covered through some time in 1988. Work relating to the effects of diet on oncogenes is in its very early development and has not been addressed as an entity per se.

The role of nutrition in neoplasia has been of longstanding concern. The subject was addressed by investigators in the first decade of this century, but was dropped. Vigorous attention was paid to this area of oncology in the 1940s, primarily due to the efforts of Dr. A. Tannenbaum at the Michael Reese Hospital in Chicago and the group at the University of Wisconsin in Madison. However, interest waned again until the 1970s when the question of diet and cancer was addressed and it has since been at the forefront of cancer research. The present volume (7) of Human Nutrition: A Comprehensive Treatise summarizes current knowledge in the area of nutrition and cancer. The first chapter is an overview written by John Higginson, whose contribution to understanding of cancer and nutrition spans several decades. The next essays cover epidemiology and physiology. The ensuing chapters address, in tum, those dietary factors relating to nutrition and cancer, namely, carbohydrates, protein, fat, cholesterol, calories, lipotropics, fiber, fruits and vegetables, vitamins, and alcohol. In a field moving as rapidly as this one is now, we can expect to miss a few late-breaking developments, but generally, the literature has been well covered through some time in 1988. Work relating to the effects of diet on oncogenes is in its very early development and has not been addressed as an entity per se.

After the appearance of the four-book series Human Nutrition: A Compre hensive Treatise, it became apparent to the editors that an important area of nutrition had been overlooked, namely, behavioral aspects of nutrition. There are two areas in which nutrition and behavior interact. On the one hand, mal nutrition may play a major role in determining behavior; alternatively, often aspects of behavior influence the eating habits of populations and individuals and thus affect their nutritional status. Volume 5 of this series speaks eloquently to both features of this important topic. Various aspects of the influence of behavior modification and nutrition have been explored by a number of qualified investigators. It is hoped that this volume will prove a valuable addition to the subjects covered in the other volumes. Roslyn B. Alfin-Slater David Kritchevsky Los Angeles and Philadelphia ix Contents Introduction: The Challenge of Nutrition and Environment as Determinants of Behavioral Development .................... . Janina R. Galler References ............................................. 5 Part I * Nutritional Deficiencies or Excesses Modifying Behavioral Outcome Chapter 1 Methological Requirements for Conceptually Valid Research Studies on the Behavioral Effects of Malnutrition David E. Barrett 1. Introduction ......................................... 9 2. Statistical-Conclusion Validity. . . . . . . . . . . . . . . . . . . . . 11 . . . . . . . 3. Internal Validity ...................................... 14 4. External Validity ..................................... 16 5. Construct Validity of Putative Causes and Effects . . . . . . . . .. . . . 19 6. Conclusions and Recommendations . . . . . . . . . . . . . . . .. . . . 28 . . . .

For a number of years, we have been teaching a course on the chemical, meta bolic, and nutritional aspects of lipids to graduate and postdoctoral students in the health sciences at the University ofCalifornia, Los Angeles. The course was taught in an "open-ended" manner-that is, after each subject was introduced, a discussion was continued for as long as necessary to explore thoroughly its cur rent status. It became evident that no text was available that could supplement the lectures adequately. This book is an attempt to remedy the deficiency and to treat extensively-although not exhaustively-most aspects of lipids, ranging from their physical and chemical properties, through biochemistry and metabolic pathways, to their role in nutrition. It is intended, as were the lectures, for those who have a basic knowledge of biochemistry, but wish to increase their know ledge of lipids. These may include graduate or advanced students, investigators preparing to enter research in lipids, clinicians, and, indeed, all those who may profit by an increased awareness ofthe importance oflipids. Although most of the subjects treated are given adequate references, it was not our intention that this book would be a complete reference source. Rather, those publications cited are deemed by the authors of each chapter to be impor tant and to lead to further reading. Inevitably, many more references are given for those subjects in which rapid advances are now being made than for those that are somewhat more static."

The science of nutrition has advanced beyond expectation since Antoine La voisier as early as the 18th century showed that oxygen was necessary to change nutrients in foods to compounds which would become a part of the human body. He was also the first to measure metabolism and to show that oxidation within the body produces heat and energy. In the two hundred years that have elapsed, the essentiality of nitrogen-containing nutrients and of proteins for growth and maintenance of tissue has been established; the ne cessity for carbohydrates and certain types of fat for health has been docu mented; vitamins necessary to prevent deficiency diseases have been identified and isolated; and the requirement of many mineral elements for health has been demonstrated. Further investigations have defined the role of these nutrients in metabolic processes and quantitated their requirements at various stages of development. Additional studies have involved their use in the possible prevention of, and therapy for, disease conditions.

The science of nutrition has advanced beyond expectation since Antoine La voisier as early as the 18th century showed that oxygen was necessary to change nutrients in foods to compounds which would become a part of the human body. He was also the first to measure metabolism and to show that oxidation within the body produces heat and energy. In the two hundred years that have elapsed, the essentiality of nitrogen-containing nutrients and of proteins for growth and maintenance of tissue has been established; the ne cessity for carbohydrates and certain types of fat for health has been docu mented; vitamins necessary to prevent deficiency diseases have been identified and isolated; and the requirement of many mineral elements for health has been demonstrated. Further investigations have defined the role of these nutrients in metabolic processes and quantitated their requirements at various stages of development. Additional studies have involved their use in the possible prevention of, and therapy for, disease conditions."

The science of nutrition has advanced beyond expectation since Antoine La voisier as early as the 18th century showed that oxygen was necessary to change nutrients in foods to compounds which would become a part of the human body. He was also the first to measure metabolism and to show that oxidation within the body produces heat and energy. In the two hundred years that have elapsed, the essentiality of nitrogen-containing nutrients and of proteins for growth and maintenance of tissue has been established; the ne cessity for carbohydrates and certain types of fat for health has been docu mented; vitamins necessary to prevent deficiency diseases have been identified and isolated; and the requirement of many mineral elements for health has been demonstrated. Further investigations have defined the role of these nutrients in metabolic processes and quantitated their requirements at various stages of development. Additional studies have involved their use in the possible prevention of, and therapy for, disease conditions."