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This book concerns the mathematical modeling and computer
simulation of the human stomach. It follows the four modern P's
(prevention, prediction, personalization, and precision in
medicine) approach in addressing the highly heterogeneous nature of
processes underlying gastric motility disorders manifested as
gastroparesis, functional dyspepsia, myenteric enteropathy etc. The
book comprehensively guides readers through the fundamental
theoretical concepts to complex physiological models of the organ.
This requires a deep and thorough understanding of driving
pathophysiological mechanisms as well as the collaborative effort
of specialists working in fundamental and biological science. Such
a multidisciplinary partnership is vital because it upholds gnostic
capabilities and provides the exchange of thoughts and ideas thus
offering broad perspectives into the evolution and management of
diseases. The book is a valuable resource for applied
mathematicians, computational biologists, bioengineers, physicians,
physiologists and researchers working in various fields of
biomedicine.
As a research subject, the biomechanics of the urinary bladder are
relatively young, yet medical problems associated with them are as
old as mankind. Offering an update on recent achievements in the
field, the authors highlight the underlying biological, chemical
and physical processes of bladder function and present the
systematic development of a mathematical model of the organ as a
thin, soft biological shell. The book will be a valuable resource
for postgraduate students and researchers interested in the
applications of computational mathematics and solid mechanics to
modern problems in biomedical engineering and medicine.
The complexity of human uterine function and regulation is one of
the great wonders of nature and represents a daunting challenge to
unravel. This book is dedicated to the biomechanical modeling of
the gravid human uterus and gives an example of the application of
the mechanics of solids and the theory of soft shells to explore
medical problems of labor and delivery. After a brief overview of
the anatomy, physiology and biomechanics of the uterus, the authors
focus mainly on electromechanical wave processes, their origin,
dynamics, and neuroendocrine and pharmacological modulations. In
the last chapter applications, pitfalls and problems related to
modeling and computer simulations of the pregnant uterus and pelvic
floor structures are discussed. A collection of exercises is added
at the end of each chapter to help readers with self-evaluation.
The book serves as an invaluable source of information for
researchers, instructors and advanced undergraduate and graduate
students interested in systems biology, applied mathematics and
biomedical engineering.
As a research subject, the biomechanics of the urinary bladder are
relatively young, yet medical problems associated with them are as
old as mankind. Offering an update on recent achievements in the
field, the authors highlight the underlying biological, chemical
and physical processes of bladder function and present the
systematic development of a mathematical model of the organ as a
thin, soft biological shell. The book will be a valuable resource
for postgraduate students and researchers interested in the
applications of computational mathematics and solid mechanics to
modern problems in biomedical engineering and medicine.
The complexity of human uterine function and regulation is one
of the great wonders of nature and represents a daunting challenge
to unravel. This book is dedicated to the biomechanical modeling of
the gravid human uterus and gives an example of the application of
the mechanics of solids and the theory of soft shells to explore
medical problems of labor and delivery. After a brief overview of
the anatomy, physiology and biomechanics of the uterus, the authors
focus mainly on electromechanical wave processes, their origin,
dynamics, and neuroendocrine and pharmacological modulations. In
the last chapter applications, pitfalls and problems related to
modeling and computer simulations of the pregnant uterus and pelvic
floor structures are discussed. A collection of exercises is added
at the end of each chapter to help readers with
self-evaluation.
The book serves as an invaluable source of information for
researchers, instructors and advanced undergraduate and graduate
students interested in systems biology, applied mathematics and
biomedical engineering.
Mathematical modelling of physiological systems promises to advance
our understanding of complex biological phenomena and
pathophysiology of diseases. In this book, the authors adopt a
mathematical approach to characterize and explain the functioning
of the gastrointestinal system. Using the mathematical foundations
of thin shell theory, the authors patiently and comprehensively
guide the reader through the fundamental theoretical concepts, via
step-by-step derivations and mathematical exercises, from basic
theory to complex physiological models. Applications to nonlinear
problems related to the biomechanics of abdominal viscera and the
theoretical limitations are discussed. Special attention is given
to questions of complex geometry of organs, effects of boundary
conditions on pellet propulsion, as well as to clinical conditions,
e.g. functional dyspepsia, intestinal dysrhythmias and the effect
of drugs to treat motility disorders. With end of chapter problems,
this book is ideal for bioengineers and applied mathematicians.
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