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Man has recognised an association of light with life and medicine
for over 3000 years. Today the major challenges to this topic
include the elucidation of photochemical reactions involved in
photobiology at the molecular level. This includes the use of a
variety of modem probing techniques that directly measures the
reactivity of excited states and free radicals involved in
biological reactions. This text-book is based on such an approach
and has arisen from some of the lectures delivered at the NATO ASI
held at Hotel Capo Caccia near the Centre for Advanced Research in
Photobiology (CARP) in Sardegia, Italy. The ASI took place from 30
September -13 October 1993 and involved a total membership of 90.
The book, like the NATO ASI itself, is divided into four themes
starting with fundamental aspects and ending with complex medically
related systems. Thus Theme 1 covers aspects of the underlying
photophysics and photochemistry with particular emphasis on modem
experimental techniques to study molecular mechanisms of biological
processes. Theme 2 applies many of these fundamental studies to the
chemical reactions of most relevance to photobiology and
photomedicine such as photo-addition, -isomerization,
-sensitization and -pigmentation. The third and fourth Themes deal
with the deleterious and therapeutic aspects of light with
particular emphasis on the use of Photo-Dynamic Therapy (PDT) to
treat cancer and on viral and micro bioi infections.
Radiation induces a variety of chemical processes in biological
tissues. This volume is a synthesis of up-to-the-minute reviews on
such photochemical and photobiological sensitized reactions with
particular relevance to photomedicine. The first part gives a
description of experimental techniques for the study of the primary
processes after radiation absorption by biological systems. It is
followed by chapters on singlet oxygen and photomedicine,
considering both phototherapy and photochemotherapy. These sections
also discuss the next generation of potential photosensitizing
drugs.
Man has recognised an association of light with life and medicine
for over 3000 years. Today the major challenges to this topic
include the elucidation of photochemical reactions involved in
photobiology at the molecular level. This includes the use of a
variety of modem probing techniques that directly measures the
reactivity of excited states and free radicals involved in
biological reactions. This text-book is based on such an approach
and has arisen from some of the lectures delivered at the NATO ASI
held at Hotel Capo Caccia near the Centre for Advanced Research in
Photobiology (CARP) in Sardegia, Italy. The ASI took place from 30
September -13 October 1993 and involved a total membership of 90.
The book, like the NATO ASI itself, is divided into four themes
starting with fundamental aspects and ending with complex medically
related systems. Thus Theme 1 covers aspects of the underlying
photophysics and photochemistry with particular emphasis on modem
experimental techniques to study molecular mechanisms of biological
processes. Theme 2 applies many of these fundamental studies to the
chemical reactions of most relevance to photobiology and
photomedicine such as photo-addition, -isomerization,
-sensitization and -pigmentation. The third and fourth Themes deal
with the deleterious and therapeutic aspects of light with
particular emphasis on the use of Photo-Dynamic Therapy (PDT) to
treat cancer and on viral and micro bioi infections.
The fIrst edition of the Science 0/ Photobiology edited by Kendric
C. Smith (plenum Press, 1977) was a comprehensive textbook of
photobiology, devoting a chapter to each of the subdisciplines of
the fIeld. At the end of many of these chapters there were brief
descriptions of simple experiments that students could perform to
demonstrate the principles discussed. In the succeeding years some
photobiologists felt that a more complete publica tion of
experiments in photobiology would be a useful teaching tool. Thus,
in the 1980s the American Society for Photobiology (ASP) attempted
to produce a laboratory manual in photobiology. Cognizant of these
efforts, Kendric Smith elected to publish the second edition of The
Science o/Photobiology (1989) without experiments; anticipating the
comple tion of the ASP laboratory manual. Unfortunately, the
initial ASP efforts met with limited success, and several years
were to pass before a photobiology laboratory manual became a
reality. One of the major stumbling blocks to production of an
accurate and reliable laboratory manual was the requirement that
the experiments be tested, not just by the author who is familiar
with the techniques, but by students who may be quite new to
photobiology. How could this be accomplished with limited
resources? Many ideas were considered and discarded, before a
workable solution was found. The catalyst that enabled the careful
screening of all experiments in this book was a NATO Advanced Study
Institute (ASI) devoted entirely to this purpose."
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