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Bone circulation is important to our understanding of many major
orthopedic conditions such as osteoarthritis, osteoporosis, repair,
and tumors. Yet, circulatory physiology, basic to all healthy
organs and most diseases, has been difficult to study in the
skeleton. The biological regulation of blood flow is complex and
the tissues have been relatively inaccessible to measurement. In
recent years, however, advances have been made in understanding
circulatory physiology and fluid flow in bone, functional
measurement of blood flow, and the roles of circulation in bone
turnover and repair. These advances have enhanced our insights into
bone homeostasis and the interrelationships of circulation and
skeletal biology, including repair and disease.This seminal volume
presents updated information on circulatory physiology of bone and
fluid flow through the bone matrix. It then describes new
techniques in quantifying and imaging bone circulation. A clinical
section covering circulatory elements of skeletal diseases provides
valuable insight into pathophysiology that may serve as diagnostic
biomarkers or therapeutic targets.
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