This comprehensive handbook explores the interactions between the practice, policy, and theory of innovation. The goal is twofold: to increase insight into this dynamic process, searching for options to improve the effectiveness and efficiency of both policy and innovative practice, and to identify conceptual or empirical lacunae and questions that can guide future research. The handbook is a joint project from 24 prominent scholars in the field, and although each chapter reveals the insights of its respective authors, two overarching theoretical perspectives provide unique coherence and consistency throughout. This original reference work will not only provide valuable insights for scholars and students on innovation studies, but also to policymakers and practitioners. Contributors: A. Bergek, K. Blind, P. Boekholt, B. Carlsson, C. Chaminade, S.E. Cozzens, B. Dankbaar, P. den Hertog, J. Edler, C. Edquist, L. Elg, S.J.H. Graham, D.H. Guston, M. Hekkert, S. Jacobsson, S. Kuhlmann, B.R. Martin, J. Molas-Gallart, D. Sarewitz, P. Shapira, K. Smith, R. Smits, M. Teubal, R. van Merkerk, G. Vissers