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The first edition of "Testosterone: Action, Deficiency, Substitu
tion" was published in 1990. Since then our understanding of the
hormone that turns males into men has tremendously increased.
Therefore, the editors felt that a second extended edition of the
book is warranted in order to summarize established and recent
findings in the field and to present the reader with an up-to-date
is reflected by the textbook. The increased mass of knowledge
growth of the volume from 14 to 20 chapters. In the updated edition
the biochemistry and metabolism of androgens have been complemented
by extensive information on the molecular biology of the androgen
receptor and its disorders. The key role of testosterone in
spermatogenesis is now better de fined. We have a more complete
understanding of the psychotro pic effects of testosterone and know
so much about the different target organs and functions that
individual chapters deal with testosterone and the prostate, lipids
and the cardiovascular sys tem, hair, bones and muscles. The
general chapter on pharmacol ogy and clinical uses of testosterone,
in particular in male hypo gonadism, is extended by pharmacokinetic
studies on testoster one preparations and individual substitution
modalities using testosterone esters as well as implants and
advanced trans dermal applications. The physiologic basis and
possible clinical applica tions of testosterone in non-gonadal
diseases, in male senes cence, in hormonal male contraception and
in transsexuals are discussed. The last chapter describes the role
of "investigative" steroid biochemistry applied to tracking
anabolic steroid abuse."
Investigations into the mechanisms of spennatogenesis, sperm matura
tion and fertilization provide the basis of our understanding of
male re productive physiology. Since in recent years molecular and
cellular en docrinology has provided particularly important
contributions to our knowledge, the European Workshops on Molecular
and Celluar Endo crinology of the Testis, held regularly during
even years since 1980, have become a prominent forum for
researchers in the field to discuss recent findings and exchange
new ideas. The most recent of these Testis Workshops, the 7th, was
held on May 5 - 10, 1992 at Castle Elmau in the Bavarian Alps. The
main lectures of this Workshops form the core of this book. In
order to provide a broader view of the current status of male re
production research, this volume also contains the proceedings of
the Schering Foundation Workshop on "Basic Mechanisms of Reproduc
tion and Male Fertility Control" which was held in Berlin on
October 31 to November 2, 1991. The topics of the two meetings were
planned to complement each other. By combining the proceedings of
both workshops, it became possible to produce a book that covers a
wide spectrum of current highlights in male reproduction research
and pro vides the reader with an up-to-date review of the field.
The timeliness of the book is emphasized by the fact that it was al
ready available when the 7th European Testis Workshop took place.
Diese definitive Anleitung wurde von Grund auf uberarbeitet und auf
den neuesten Stand gebracht fur alle Laboratorien, die sich mit der
Analyse des menschlichen Ejakulates beschaftigen. Das Handbuch
liefert fundamentale Labortechniken fur die Diagnose der mannlichen
Infertilitat. Der Text beschreibt die Zusammenstellung eines
konventionellen Samenprofils anhand von standardisierten
Protokollen fur verschiedene fakultative diagnostische Verfahren.
Solche Techniken sind unentbehrlich fur die Evaluierung infertiler
Paare sowie der Fertilitat von Mannern, deren Spermienproduktion
durch potentielle mannliche Kontrazeptiva oder toxische Substanzen
unterdruckt wird. Auch fur die Gerichtsmedizin und kunstliche
Insemination sind sie von Interesse. Vorangehende Auflagen dieses
Manuals haben sich auf dem Gebiet der Erforschung und Behandlung
der mannlichen Fertilitat etabliert; diese Neuauflage fuhrt diese
Tradition fort und wird als Standard fur zukunftige strengere
Massstabe dienen."
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