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This volume is based on the proceedings of a NATO Advanced Research Workshop on Slow Potential Changes in the Human Brain that was held at II Ciocco, Tuscany, Italy over the period 13-16th May, 1990. The Workshop Director was Dr. W. C. McCallum of the Burden Neurological Institute, Bristol, England. The meeting was superbly organised and proved to be both stimulating and productive. On behalf of everyone who attended the meeting, I would like to II Ciocco for express my appreciation to NATO for the provision of funding and to providing such a marvellous conference venue. I must apologise to everyone who has contributed to this volume for the length of time it has taken to produce a finished book. As you are all aware, the untimely death of Cheyne McCallum, who was to have been the sole editor of this volume, was very disruptive to both the book and myself. Following Cheyne's death I assumed the responsibility for completing the book as was his wish. I would like to thank you all for your patience and understanding. I would like to acknowledge my indebtedness to the Burden Neurological Institute in general and very specifically to Mrs. Chris Gough who has laboured extensively in the production of this volume.
This volume is based on the proceedings of a NATO Advanced Research Workshop on Slow Potential Changes in the Human Brain that was held at II Ciocco, Tuscany, Italy over the period 13-16th May, 1990. The Workshop Director was Dr. W. C. McCallum of the Burden Neurological Institute, Bristol, England. The meeting was superbly organised and proved to be both stimulating and productive. On behalf of everyone who attended the meeting, I would like to II Ciocco for express my appreciation to NATO for the provision of funding and to providing such a marvellous conference venue. I must apologise to everyone who has contributed to this volume for the length of time it has taken to produce a finished book. As you are all aware, the untimely death of Cheyne McCallum, who was to have been the sole editor of this volume, was very disruptive to both the book and myself. Following Cheyne's death I assumed the responsibility for completing the book as was his wish. I would like to thank you all for your patience and understanding. I would like to acknowledge my indebtedness to the Burden Neurological Institute in general and very specifically to Mrs. Chris Gough who has laboured extensively in the production of this volume.
Drug Disposition and Pharmacokinetics The most up-to-date edition of a leading reference in drug disposition and pharmacokinetics In this new, fully-revised edition of Drug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology the authors deliver an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics. This latest edition provides readers with a new introductory chapter, as well as new chapters covering monoclonal antibodies, the role of stereochemistry in drug disposition and pharmacokinetics, DMPK in non-human species, and the recent use of AI in drug development. Readers will also find: Thorough introductions to drug disposition, pharmacokinetics, and pharmacokinetic modeling In-depth treatments of the kinetics of drug elimination and the relationship between concentration and effect, including PK-PD modeling Comprehensive discussions of predictive pharmacokinetics and the disposition of biological molecules, including peptides and monoclonal antibodies Detailed examinations of the effects of sex, pregnancy, age, and disease, as well as drug monitoring in therapeutics and the use of AI in drug development and treatment Perfect for professionals and researchers working with the scientific aspects of drug disposition in human and veterinary medicine, toxicology, and pharmacology. Drug Disposition and Pharmacokinetics will earn a place in the libraries of students of senior-level courses in pharmacy.
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