This volume gathers the latest advances, innovations, and applications in the field of robotics engineering, as presented by leading international researchers and engineers at the Latin American Symposium on Industrial and Robotic Systems (LASIRS), held in Tampico, Mexico on October-November 30-01 2019. The contributions cover all major areas of R&D and innovation in simulation, optimization, and control of robotics, such as design and optimization of robots using numerical and metaheuristic methods, autonomous and control systems, industrial compliance solutions, numerical simulations for manipulators and robots, metaheuristics applied to robotics problems, Industry 4.0, control and automation in petrochemical processes, simulation and control in aerospace and aeronautics, and education in robotics. The conference represented a unique platform to share the latest research and developments in simulation, control and optimization of robotic systems, and to promote cooperation among specialists in machine and mechanism area.