Nitric oxide (NO) is a simple gas with free radical properties. No one would have imagined a role for such a simple substance in the human body. In 1998, R. E Furchgott, E Murad, and L. J. Ignarro received the Nobel prize for their work on NO. Interestingly, Alfred B. Nobel, who invented dynamite by combining nitro glycerin with other substances, took nitroglycerin for his chest pain without realizing that NO mediates its action. Now, in addition to its vasodilating action, NO is known to possess many fundamental functions that include neurotrans mission, blood pressure control, blood clotting, and immune responses. These diverse functions, conversely, imply that the simple NO molecule may unite neuroscience, physiology, and immunology and may change our understanding of how cells communicate and defend themselves. In this context, the Inter national Symposium, Nitric Oxide and Free Radicals, was organized to address current thinking about the widespread distribution and variety of functions of NO in the eye. The symposium was held in Kyoto, Japan, September 28-29 as a Satellite Symposium of the XII International Congress of Eye Research, 1996. The Symposium was the first international gathering of leading scientists and ophthalmologists meeting to present and discuss their most recent results in a specialized area of research, specifically concerning the eye.

The diverse roles in physiological function now attributed to nitric oxide include those it performs in the eye. In recent years this simple molecule has become the subject of increased attention among researchers and practitioners concerned with the eye. While most books in the field have concentrated on the pharmacology of NO in the central and peripheral nervous system or the cardiovascular system, the contents of this volume encompass all aspects of the eye and NO. With authors who are leading scientists worldwide, the major sections include reports of the latest research in the mechanism of ocular hypertension and glaucoma (aqueous dynamics), ocular autonomic neurotransmission (ocular bloodflow), and the pathophysiology of uveitis; the final section contains three chapters on the role of NO specific to the retina. This book is a valuable resource for researchers as well as for ophthalmologists and other practitioners interested in the role of NO in the eye.